Acrodermatitis Enteropathica in the Pediatric Population: A Literature Review of Real-World Studies

    June 2025 in “ Frontiers in Nutrition ”
    Wanlin Cui, Ningning Wang, Mingyue Shi … Hongkun Jiang
    Studysummary This study reviewed literature on pediatric acrodermatitis enteropathica and found that zinc deficiency occurred in 75.9% of cases, with zinc supplementation showing therapeutic efficacy in 91.4% of patients; however, it was often ineffective in those with underlying metabolic disorders.
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    Research cited in this study 14

    1. Acrodermatitis Dysmetabolica Secondary to Isoleucine Deficiency in Infant With Maple Syrup Urine Disease Dermatology reports · 2023
    2. Case Report: Acrodermatitis Enteropathica Resulting From a Novel SLC39A4 Gene Mutation Frontiers in pediatrics · 2022
    3. Acquired Acrodermatitis Enteropathica in an Infant Cutis · 2022
    4. A Rare Case of Severe Acrodermatitis Enteropathica During COVID-19 Lockdown JAMC. Journal of Ayub Medical College, Abbotabad, Pakistan/Journal of Ayub Medical College · 2022
    5. Analysis of the Relationship Between the Mutation Site of the SLC39A4 Gene and Acrodermatitis Enteropathica: A Case Report and Literature Review BMC pediatrics · 2020
    6. Acrodermatitis Enteropathica-Like Skin Eruption With Neonatal Seizures in a Child With Biotinidase Deficiency Clinical and experimental dermatology · 2019
    7. Acrodermatitis Dysmetabolica in an Infant with Maple Syrup Urine Disease Clinical and Experimental Dermatology · 2016
    8. Man-Made Disease: Clinical Manifestations of Low Phenylalanine Levels in an Inadequately Treated Phenylketonuria Patient and Mouse Study Molecular genetics and metabolism · 2013
    9. Zinc And Biotin Deficiencies After Pancreaticoduodenectomy PubMed · 2010
    10. Congenital Zinc Deficiency from Mutations of the SLC39A4 Gene as the Genetic Background of Acrodermatitis Enteropathica Journal of Korean medical science/Journal of Korean Medical Science · 2010
    11. A Case of Acquired Acrodermatitis Enteropathica with a Normal Serum Zinc Level but a Low Level in the Hair Korean Journal of Pediatrics · 2007
    12. Acrodermatitis Enteropathica-Like Eruption in an Infant with Nonketotic Hyperglycinemia Journal of dermatology · 2000
    13. Acrodermatitis Enteropathica: Case Report Analyses of Zinc Metabolism, Electron Microscopic Examination, and Immune Function The Journal of Trace Elements in Experimental Medicine · 2000
    14. Polarization Microscopy of Hair in Acrodermatitis Enteropathica Pediatric dermatology · 1986