August 2026 in “Clinical Cosmetic and Investigational Dermatology” This review synthesizes current knowledge on acral vitiligo, highlighting its treatment resistance, psychosocial impact, and emerging therapies like JAK inhibitors, while identifying knowledge gaps and future research directions.
December 2025 in “Cureus” In this report, successful management of inherited acrodermatitis enteropathica, a zinc absorption disorder due to an SLC39A4 gene defect, was demonstrated in an infant through zinc supplementation.
November 2025 in “American Journal of Case Reports” This case report describes a child with acrodermatitis enteropathica and normal zinc levels who developed Kaposi's varicelliform eruption, highlighting the role of novel SLC39A4 variants and the importance of early zinc supplementation and antiviral prophylaxis.
November 2025 in “Journal of Saidu Medical College Swat” In this case report, a 2.5-year-old boy with biotinidase deficiency, initially misdiagnosed due to overlapping symptoms, showed dramatic improvement in several clinical areas after starting biotin supplementation, but persistent sensorineural hearing loss underscored the importance of early diagnosis for preventing irreversible complications.
October 2025 in “BMC Pediatrics” This case report describes an 8-year-old boy with acrodermatitis enteropathica who showed significant recovery from severe symptoms after receiving a therapeutic zinc supplement.
October 2025 in “Frontiers in Medicine” In this case report, a 10-month-old ethnic minority infant from Xinjiang with acrodermatitis enteropathy improved clinically and biochemically after zinc supplementation, underscoring the importance of early genetic testing for SLC39A4 mutations and individualized zinc therapy in managing this disorder.
October 2025 in “Indian Journal of Paediatric Dermatology” This case study documents a boy with zinc-responsive acral hyperkeratosis improving significantly after zinc supplementation, suggesting it could result from inadequately treated acrodermatitis enteropathica.
October 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This case report describes a 10-month-old minority infant from Xinjiang, China, with acrodermatitis enteropathy due to a SLC39A4 genetic mutation, showing clinical improvement in skin, hair, and zinc levels following zinc supplementation and highlighting the importance of early diagnosis and tailored treatment.
October 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this case study, a 10-month-old minority infant from Xinjiang, China, with acrodermatitis enteropathy caused by an SLC39A4 gene mutation showed clinical improvement and increased zinc levels following zinc supplementation, highlighting the importance of early genetic testing and customized treatment in managing the disorder.
August 2025 in “Current Botany” This study suggests that Acrotrema arnottianum, a herb used in traditional medicine, contains biologically active metabolites like squalene and α-Tocopherol. It showed antibacterial effects against Staphylococcus aureus and antifungal properties against Candida albicans, while demonstrating antioxidant activity.
August 2025 in “International Journal of Research in Dermatology” This case report highlights an atypical presentation of acrodermatitis enteropathica in an 18-year-old male, exhibiting symptoms like erythrokeratoderma variabilis with a positive response to high-dose oral zinc, underscoring the importance of considering zinc deficiency in unusual skin conditions.
In this case study, a 51-year-old woman with acquired acrodermatitis enteropathica linked to nutritional zinc deficiency showed significant improvement in skin and hair symptoms one week after receiving zinc gluconate, topical applications, and supportive TPN therapy, highlighting the importance of early recognition and treatment.
April 2025 in “Indian Journal of Paediatric Dermatology” This case report describes a 7-month-old girl diagnosed with acrodermatitis enteropathica, linked to low zinc levels, whose skin lesions improved significantly after zinc supplementation.
In this case report, a two-year-old girl with acrodermatitis enteropathica was misdiagnosed for over a year before low serum zinc levels led to the correct diagnosis, and her skin lesions resolved completely after two weeks of zinc sulfate treatment.
August 2024 in “Turkish Journal of Pediatric Disease” This case report details a 5-month-old infant with acrodermatitis enteropathica, linked to zinc deficiency from total parenteral nutrition, who showed improvement using zinc spray and cream, contrasting with typical literature outcomes.
January 2024 in “JAAD case reports” This study discusses zinc's vital role in skin cell growth and how its deficiency can lead to acrodermatitis enteropathica, marked by symptoms like alopecia and dermatitis. It notes that similar symptoms appear in people with certain metabolic conditions, referred to as acrodermatitis dysmetabolica.
August 2023 in “Dermatology reports” This case study of a 2-month-old boy with maple syrup urine disease highlights the dangers of restricting branched-chain amino acid intake, as it led to acrodermatitis dysmetabolica-like skin eruptions and hair loss, later resolved with careful dietary adjustments and monitoring.
February 2023 in “Research Square (Research Square)” This case report describes a 16-month-old girl with atypical acrodermatitis enteropathica who showed marked improvement after zinc supplementation despite normal serum zinc levels.
January 2023 in “Open journal of pediatrics” In this case report, a 7-month-old girl with suspected acrodermatitis enteropathica and severe dermatitis experienced a tragic outcome despite zinc treatment, highlighting the challenges of diagnosing and managing this rare genetic disorder.
December 2022 in “Indian Journal of Animal Research” This study found that both fluoxetine and clomipramine are effective in treating psychogenic triggers of acral lick dermatitis in dogs, with fluoxetine leading to quicker recovery and lower recurrence rates, while clomipramine showed better overall recovery rates but was associated with fewer side effects.
December 2022 in “Exploratory animal and medical research” This study found that acral lick dermatitis in dogs has a higher prevalence in young male dogs, especially Labrador retrievers, during colder months, with psychogenic triggers being the most common cause.
November 2022 in “Frontiers in pediatrics” This case report found that a child with acrodermatitis enteropathica showed significant improvement in symptoms after continuous zinc supplementation and identified two SLC39A4 mutations through genetic sequencing.
This case report describes a 3-month-old infant with acquired acrodermatitis enteropathica who was successfully treated with zinc supplementation over 3 weeks.
September 2022 in “JAMC. Journal of Ayub Medical College, Abbotabad, Pakistan/Journal of Ayub Medical College” This case study reports that zinc supplementation significantly improved the symptoms of Acrodermatitis Enteropathica in a 12-year-old boy, emphasizing the importance of early diagnosis and treatment compliance.
September 2022 in “Research Square (Research Square)” This study found that caffeic acid treatment mitigated the negative effects of acrylamide toxicity in Wistar rats by normalizing tissue and serological indices.
December 2020 in “Macromolecular Symposia” This study found that incorporating acrylic and methacrylic acid into poly(N-vinyl-2-pyrrolidone) copolymers improves film mechanical properties but negatively affects their interaction with keratin for hair care applications.
April 2020 in “Journal of evolution of medical and dental sciences” This report reviews the clinical presentation and genetic aspects of a case of acrodermatitis enteropathica in a one-year-old child but provides no new clinical findings.
January 2020 in “Turkish Journal of Dermatology” This case report describes a 9-month-old boy with zinc deficiency-related symptoms, including hair loss and diarrhea, ultimately diagnosed as acrodermatitis enteropathica and improved with zinc therapy.
This study identified rare nucleotide substitutions in the SLC39A4 gene in children with acrodermatitis enteropathica, suggesting a genetic component to the disease's etiology.
December 2016 in “Journal of Evolution of Medical and Dental Sciences” This case report highlights that inherited zinc deficiency can persist into adulthood and emphasizes the importance of selecting optimal chelating agents to improve oral zinc bioavailability.