TLDR Zinc supplements effectively treat inherited zinc deficiency in infants.
Acrodermatitis enteropathica (AE) is a severe zinc deficiency disorder, either genetic or acquired, with symptoms including periorificial dermatitis, alopecia, and diarrhea. This case report focuses on an infant with inherited AE, effectively treated with zinc supplementation. Diagnosis relies on clinical evaluation, serum zinc levels, and histopathology, as genetic testing might not be accessible. Early detection and zinc treatment are vital to avoid morbidity, and lifelong supplementation is required for congenital cases.
16 citations
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January 2010 in “Journal of Korean medical science/Journal of Korean Medical Science” A Korean boy's skin and digestive symptoms were caused by a rare genetic disorder that affects zinc absorption, and he got better with zinc supplements.
April 2020 in “Journal of evolution of medical and dental sciences” A one-year-old child with a genetic condition had symptoms improved by treating zinc deficiency.
11 citations
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January 2020 in “BMC pediatrics” New mutations in the SLC39A4 gene found in twins help understand the genetic cause of acrodermatitis enteropathica.
November 2022 in “Frontiers in pediatrics” A girl with skin rashes and low zinc levels improved with zinc supplements and had new gene mutations linked to her condition.
5 citations
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April 2013 in “Nasza Dermatologia Online” Oral zinc therapy is effective for treating acrodermatitis enteropathica.
August 2025 in “International Journal of Research in Dermatology” Increasing zinc intake improved skin and hair symptoms in a rare genetic disorder.