Acrodermatitis Dysmetabolica With Concomitant Acquired Acrodermatitis Enteropathica in a Patient With Maple Syrup Urine Disease
January 2024
in “
JAAD case reports
”
Studysummary This study discusses zinc's vital role in skin cell growth and how its deficiency can lead to acrodermatitis enteropathica, marked by symptoms like alopecia and dermatitis. It notes that similar symptoms appear in people with certain metabolic conditions, referred to as acrodermatitis dysmetabolica.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
A 24-year-old woman with maple syrup urine disease (MSUD) exhibited symptoms of acrodermatitis dysmetabolica (AD) and acquired acrodermatitis enteropathica (AE), including a nonpruritic skin eruption, diarrhea, and hair loss, due to deficiencies in leucine, valine, zinc, and albumin. Despite supplementation, she died from sepsis. This case underscores the need for careful monitoring and balancing of branched-chain amino acids (BCAAs) and zinc levels in MSUD patients to prevent AD and AE-like symptoms.
