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    Glossary Acantholysis

    breakdown of connections between skin cells causing separation

    Acantholysis is a condition where the connections between skin cells break down, causing the cells to separate from each other. This leads to the formation of blisters and can be seen in diseases like pemphigus vulgaris. Essentially, it's a breakdown in the "glue" that holds skin cells together, resulting in fragile skin that can easily blister or peel.

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    1. Distinguishing histopathologic features of acantholytic dermatoses and the pattern of acantholytic hypergranulosis Journal of cutaneous pathology · 2018 · 20 citations
    2. Acantholytic hair casts: A dermoscopic sign of pemphigus vulgaris of the scalp International Journal of Trichology · 2012 · 15 citations
    3. Acanthosis nigricans, insulin resistance and cutaneous virilism British Journal of Dermatology · 1988 · 43 citations
    4. Acanthosis nigricans and the metabolic syndrome Clinics in Dermatology · 2017 · 30 citations
    5. Insulin Resistance, Acanthosis Nigricans, and Polycystic Ovaries Associated with a Circulating Inhibitor of Postbinding Insulin Action The Journal of Clinical Endocrinology & Metabolism · 1985 · 24 citations
    6. Implications of a Clinically Ignored Site of Acanthosis Nigricans: The Knuckles Experimental and Clinical Endocrinology & Diabetes · 2014 · 9 citations
    7. Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome Case reports in endocrinology · 2015 · 7 citations
    8. Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance Dermato-endocrinology · 2018 · 6 citations
    9. A case of hyperpigmentation and acanthosis nigricans by testosterone injections Human & experimental toxicology · 2014 · 6 citations
    10. Global hotspots and trends in Acanthosis nigricans research: A bibliometric and visualized analysis Skin Research and Technology · 2024 · 3 citations
    11. Mania in Hyperandrogenism, Insulin Resistance, and Nigricans Acanthosis Syndrome ˜The œAmerican journal of psychiatry · 2002 · 3 citations
    12. A case of severe hyperandrogenism, acanthosis nigricans and overt diabetes: the use of non-invasive methods for diagnosis, pathogenesis and management Gynecological endocrinology · 1996 · 1 citations
    13. Ectopic acanthosis nigricans at a post-syndactyly surgical site: An unusual reactive epidermal phenomenon Journal of Cutaneous and Aesthetic Surgery · 2026
    14. Role of Metformin in Acanthosis Nigricans International Journal of Dermatology Venereology and Leprosy Sciences · 2026
    15. Hyperandrogenism insulin resistance-acanthosis nigricans syndrome in a female adolescent with migraine: A case report Indian Journal of Physiology and Pharmacology · 2025
    16. Acanthosis nigricans in adolescents with polycystic ovary syndrome International journal of reproduction, contraception, obstetrics and gynecology · 2022
    17. ACANTHOSIS NIGRICANS IN OBESE VERSUS NON-OBESE IN A TERTIARY CARE HOSPITAL ASSOCIATION WITH BMI AND CENTRAL OBESITY Zenodo (CERN European Organization for Nuclear Research) · 2021
    18. Acanthosis Nigricans during an HAIR-AN syndrome: "The Tree That Hides the Forest" Journal of clinical & experimental dermatology research · 2017
    19. Hyperandrogenism-insulin resistance-acanthosis nigricans syndrome with PCOS and Hashimoto's thyroiditis: case report International Journal of Research in Medical Sciences · 2015
    20. Acanthosis nigricans, insulin resistance and cutaneous virilism 1988
    21. Papular Acantholytic Dyskeratosis of the Vulva: A Case Report and Literature Review Clinical Cosmetic and Investigational Dermatology · 2025 · 4 citations
    22. Ultraviolet-Induced Fluorescence and Sub-Ultraviolet Reflectance Dermatoscopy of Grover’s Disease (Transient Acantholytic Dermatosis): a Retrospective Single-Center Cohort Study Dermatology Practical & Conceptual · 2025
    23. The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome: therapeutic response Fertility and sterility · 1994 · 23 citations
    24. Review of facial acanthosis nigricans: Easy to diagnose and difficult to treat marker of hyperinsulinemia/metabolic syndrome Medical Journal Armed Forces India · 2024 · 2 citations
    25. Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation Molecular and cellular biology · 2002 · 108 citations
    26. Pemphigus Vulgaris IgG and Methylprednisolone Exhibit Reciprocal Effects on Keratinocytes Journal of Biological Chemistry · 2004 · 99 citations
    27. Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs PLoS ONE · 2012 · 28 citations
    28. Alopecia as a rare but distinct manifestation of pemphigus vulgaris Journal of the European Academy of Dermatology and Venereology · 2011 · 23 citations
    29. Miniaturization of sebaceous glands: A novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp Journal of Cutaneous Pathology · 2017 · 9 citations
    30. Heterozygous Arrhythmogenic Cardiomyopathy-desmoplakin Mutation Carriers Exhibit a Subclinical Cutaneous Phenotype with Cell Membrane Disruption and Lack of Intercellular Adhesion Journal of Clinical Medicine · 2021 · 4 citations