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This study found that lichen planopilaris is associated with three core molecular pathways, which may inform new therapeutic strategies for scarring alopecia, including unique pathways like ABC transporters specific to LPP.

This study observed that patients with androgenetic alopecia had significantly higher serum FABP4 levels compared to healthy controls, suggesting FABP4 may be involved in the condition's pathogenesis.

This study found that sebum free fatty acids may enhance the antibacterial defense of human sebaceous glands by upregulating the expression of the antimicrobial peptide hBD-2, potentially aiding in acne treatment.

The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.

This study reports that the fatty acid composition in cell membranes of stratified squamous epithelium varies with keratinization patterns, showing a partial essential fatty acid-deficient state in cultured keratinocytes.

This study found that in genetically diabetic mice, supplementation with safflower or evening primrose oil prevented the decrease in certain fatty acids and improved skin conditions, but increased plasma glucose levels.

This study reported that a 19-year-old man's essential fatty acid deficiency was reversed with daily topical application of linoleic acid, improving clinical symptoms and normalizing certain fatty acid levels.

This study found that pigs fed a fat-free diet had significantly less body dry matter and ether extract compared to those consuming a diet with corn oil, although weight gain was unaffected by the fat content.

This review discusses the essential role of linoleic acid in preventing deficiency symptoms and enhancing skin function, but notes that scientific knowledge on its potential therapeutic use for skin diseases remains limited.

In this study, dogs fed Diet B with specific levels of dietary zinc and linoleic acid showed improved skin and hair coat conditions, evidenced by increased hair follicle growth and higher skin lipid scores.

This study found that the application of polyunsaturated fatty acids, particularly arachidonic acid, promoted hair growth and anagen induction in both human dermal papilla cells and mouse models.

This study reports that polyunsaturated fatty acids, particularly arachidonic acid alone and combined with eicosapentaenoic acid, may stimulate hair growth and enhance hair growth factors in mice and human dermal cells.

This review explains that linoleic acid deficiency can lead to skin and growth issues but notes that such deficiencies are rare in well-nourished Western populations; it reports no new clinical findings.

In this case report, applying linoleic acid topically reversed essential fatty acid deficiency and related skin symptoms in a patient receiving long-term fat-free intravenous nutrition.

This case report found that a linoleic acid topical application reversed essential fatty acid deficiency and improved scalp dermatitis, alopecia, and hair depigmentation in a 19-year-old patient on fat-free intravenous nutrition.

This study found that essential fatty acid deficiency in rabbits leads to significant degeneration of gonadal tissue, possibly due to impaired anterior pituitary gland function.

This study suggests that gel containing OSF3 loaded in niosomes offers high transfollicular penetration for topical anti-androgenic alopecia treatment with minimal systemic effect.

This study reports that polyphenols from Annurca apples may safely promote hair growth and protect against chemotherapy-induced alopecia without interfering with chemotherapy regimens.

This letter discusses how outdated measurement technology may obscure evidence of essential fatty acid deficiency in low-fat diet patients, potentially leading to undiagnosed EFA insufficiencies related to heart disease.

This study found that feeding mice a high-fat diet with fish oil leads to hair loss through a mechanism involving omega-3 fatty acids and TNF-α signaling, with epidermal fatty acid binding protein playing a key role.

This study provides conclusive evidence of exogenous calcium fatty acid deposits forming between the cuticle layers in hair, affecting its optical and mechanical properties.

This study found that environmental conditions significantly influenced rabbit coat quality, while dietary linseed oil supplementation changed the fatty acid profile but did not improve coat thickness or heat protection.

This study found that Phaeodactylum tricornutum extract enhanced hair follicle cell proliferation, indicated by increased keratin and ERK1/2 signaling, suggesting its potential for hair care applications.

This study used molecular dynamics simulations to model the outer surface of human hair, illustrating complex behavior and potential adsorption interactions with fatty acids, which may inform cosmetic formulation development.

This scoping review reports that preclinical studies suggest omega fatty acids may promote hair follicle growth, but clinical evidence is mixed, with no support for their standalone use in treating alopecia.

This randomized, placebo-controlled trial reported that USPlus PRO saw palmetto extract significantly improved lower urinary tract symptoms, including voiding, incomplete emptying, and weak stream, as well as sexual function in males over 12 weeks, while maintaining a favorable safety profile.

This study found that a proprietary saw palmetto (Serenoa repens) extract significantly increased hair growth and reduced hair shedding in men and women with self-perceived thinning hair over a 90-day period, compared to placebo, without reported adverse events.

This study observed that topical application of palmitate or oleate accelerated the onset of the hair growth phase in mice, whereas glycolysis end product lactate delayed it, suggesting metabolic regulation as a promising approach for influencing hair growth.

This study suggests that a supercritical CO2 extract from wild-strawberry-processing waste may be an innovative and sustainable ingredient for cosmetic applications, particularly in treating androgenic-related skin conditions.

This review discusses PUFA-rich oil seeds and microencapsulation techniques but reports no new clinical results; the authors highlight microencapsulation as a promising method to protect PUFAs from oxidation.