Molecular Phenotyping of Lichen Planopilaris Revealed Dysregulation of Cholesterol/Fatty Acid Metabolism, Fibrosis, and Mast Cell Pathways
April 2019
in “
Journal of Investigative Dermatology
”
lichen planopilaris scarring alopecia RNAseq steroid pathways cholesterol pathways fatty acid pathways fibrosis hypertrophic scarring mast cell pathways ABC transporter pathways LPP scarring hair loss RNA sequencing steroid metabolism cholesterol metabolism fat metabolism mast cells ABC transporters
Studysummary This study found that lichen planopilaris is associated with three core molecular pathways, which may inform new therapeutic strategies for scarring alopecia, including unique pathways like ABC transporters specific to LPP.
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