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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

The document concludes that alopecia has significant social and psychological effects, leading to a market for hair loss treatments.

Certain natural compounds can block an enzyme linked to prostate enlargement and hair loss, showing potential for new treatments.

The R343H mutation in the VDR gene causes vitamin D-resistant rickets with alopecia by impairing specific gene activity.

Two types of 5α-reductase are in dog skin, which might make dutasteride better than finasteride for treating dog hair loss.

New indole-based compounds, particularly cemtirestat, show promise as dual-function drugs for diabetic complications.

Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

Using 5-alpha-reductase inhibitors, drugs for prostate issues and hair loss, may lead to eye abnormalities in men.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Four-amino acid part makes enzyme sensitive to finasteride.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Certain drugs that block specific enzymes can help treat prostate diseases.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

Certain drugs change freshwater snail shells to a "banana" shape.

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

A new compound effectively inhibits human 5α-reductase 1.

Finasteride doesn't improve survival in LNCaP tumor model during off-cycle of therapy.

Gene mutations can cause problems in male genital development.