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New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.

Isoallopregnanolone may be a safe and effective treatment for reducing tics in a mouse model of Tourette syndrome.

Progesterone treatment improved seizures in a woman with menstrual cycle-related epilepsy, but a wrong medication worsened her condition.

The effects of estrogen on human scalp hair growth are unclear and need more research.

Neuroimaging suggests that treatments targeting brain steroids could help control epilepsy, especially types linked to the menstrual cycle.

Finasteride treats hair loss but may cause low libido, erectile issues, and depression.

Finasteride may not affect gynecomastia recurrence after mastectomy.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

Personalized treatment with inhibitors, minoxidil, and laser therapy helps hair loss.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Finasteride can cause sexual dysfunction and depression, which may persist and require hormonal treatment.

Finasteride blocks progesterone production in specific tumor cells, potentially causing side effects.

Finasteride treats baldness but may cause lasting sexual side effects.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

Finasteride helps protect brain in old male rats.

5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.