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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Ageratum conyzoides L. extract may effectively and safely treat hair loss.

Ficus benghalensis leaf extracts can effectively promote hair growth and inhibit hair loss.

Idiopathic hirsutism causes excessive hair growth in women, can be treated with medication and hair removal, but cannot be fully reversed.

Minoxidil and finasteride effectively treat hair loss.

Finasteride and CPA-EE2 equally reduce hirsutism, but affect hormone levels differently.

The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.

Ganoderma lucidum may help treat prostate cancer by blocking male hormones and slowing cancer cell growth.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride negatively affects fish reproduction and gonadal development.

Low dose finasteride decreases certain steroids, possibly increasing depression risk.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Finasteride helps reduce pain and inflammation in animals.

Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.

Dutasteride 0.5 mg daily improves hair growth safely in men with hair loss.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Treating hirsutism in women often requires a mix of medications and cosmetic methods for best results.

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

Hair restoration for East Asians should consider their unique characteristics like head shape, hair thickness, and hair density, and use modified procedures and treatments to minimize scarring and maintain hair density.

Minoxidil and finasteride combo maintains hair density effectively.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.