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A 15-year-old girl with no menstrual period was diagnosed with a genetic condition that makes her body unable to respond to male hormones, leading to female characteristics despite having male genetic makeup.

Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.

A Saudi individual initially identified as a girl had a genetic disorder affecting gender development.

The first pediatric case of naevus trichilemmocysticus was documented.

A 13-year-old with 46 XY DSD had ambiguous genitalia due to incomplete masculinization.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

The conclusion is that lifestyle changes and weight loss are first-line treatments for infertility due to anovulation, with various medications and assisted reproductive technologies as additional options.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

Understanding normal hair growth and loss in children is key to diagnosing and treating hair disorders.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

A man with both Klinefelter syndrome and primary hyperparathyroidism showed a rare combination of symptoms and genetic patterns.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

DHT, a testosterone byproduct, causes male pattern baldness.

The girl's unexpected pubic hair growth led to a diagnosis different from complete androgen insensitivity syndrome.

Zouboulis syndrome is a rare condition that helps diagnose monosomy 18p early.

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

Finasteride may negatively affect male fertility.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Gene mutations can cause problems in male genital development.

Hormonal imbalances are a key cause of missed menstrual periods in women.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Testosterone is crucial for development, growth, and various body functions in mammals.

A 19-year-old male had two rare skin conditions causing scarring and permanent hair loss.