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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Sebocytes play a key role in controlling androgen levels in human skin.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

Finasteride helps protect brain in old male rats.

Finasteride doesn't affect sleep spindles in men.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Finasteride reduces new brain cells in male mice, possibly causing depression.

Sulforaphane may help with hair growth by breaking down a hormone that causes hair loss.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

Vitamin E affects liver metabolism, enhancing stress resistance, reducing blood clotting, and altering hormone processing.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

A mix of sulforaphane, L-menthol, and dexpanthenol could help increase hair growth and reduce hair loss.

Finasteride may cause slight depression and anxiety.

Finasteride use can cause depression-like behavior in male rats.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Dihydrotestosterone causes p27 protein breakdown in ovarian and breast cancer cells by binding with SKP2.

Finasteride can treat hair loss, but may have side effects; evaluate and inform patients of risks.

New signs like changes in blood markers, physical symptoms, and behavioral shifts may help detect hidden steroid use in athletes.

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Eating alfalfa sprouts every day can raise testosterone levels in middle-aged men, but broccoli sprouts don't have this effect.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.