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Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.

Copper deficiency may cause hair loss, and treating it could involve nutrition and hormones.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Treating hirsutism in women often requires a mix of medications and cosmetic methods for best results.

Regulating certain sex hormones may help delay facial aging.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

COVID-19 can cause different skin symptoms that may help with early diagnosis and show how severe the disease is.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Early diagnosis and treatment of TPP can prevent complications.

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.

Hair loss involves immune responses, inflammation, and disrupted signaling pathways.

Arctiin helps protect hair cells from damage and death caused by oxidative stress.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Monascus helps prevent baldness, prostate issues, and may be a natural alternative to medications.

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

The conclusion is that analyzing RNA from skin oils is a promising way to understand skin diseases.