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Did you mean Estrogen Receptor Antagonist?

Glossary Estrogen Receptor Antagonist

blocks estrogen from activating its cellular receptors

An Estrogen Receptor Antagonist, also known as an Estrogen Blocker or ER Antagonist, is a substance that binds to estrogen receptors on cells and prevents estrogen from exerting its effects. This can be useful in treating conditions like hormone-sensitive cancers, such as certain types of breast cancer, by inhibiting the growth-promoting effects of estrogen on these cancer cells.

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Research

5 / 1000+ results

research Oestrogen receptor antagonist and hair regrowth in dogs with hair cycle arrest (alopecia X)

11 citations , January 2007 in “Veterinary dermatology”

This study found that administerating 10 mg/kg intramuscular fulvestrant did not stimulate hair regrowth in Pomeranian dogs with alopecia X, though higher doses may warrant further investigation.

research On the Effect of Estrogen Receptor Agonists and Antagonists on the Mouse Hair Follicle Cycle

11 citations , July 1998 in “Journal of Investigative Dermatology”

β-estradiol slows hair growth in mice.

research Failure of Topical Estrogen Receptor Agonists and Antagonists to Alter Murine Hair Follicle Cycling

8 citations , January 1998 in “Journal of Investigative Dermatology”

This study did not find any significant effects of estradiol or its antagonists on hair growth in two common mouse strains, challenging previous results reported by Oh and Smart.

research An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.

154 citations , October 1996 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that 17-beta-estradiol inhibits hair growth in mice by blocking hair follicles in the telogen phase, whereas an estrogen receptor antagonist promotes hair growth by initiating anagen.

research 17β-Estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen receptor-α pathway

71 citations , February 2000 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism”

This study found that topical estradiol inhibits hair growth in mice by preventing the hair follicle's transition from resting to growth phase, a process reversible with an estrogen receptor antagonist.

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Community Join

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community Breezula phase 3 results said to be released next month

26 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community High Estrogen causing hair loss?

16 upvotes 3 years ago

A 24-year-old male using topical finasteride for hair loss is experiencing thinning despite treatment and has high estrogen levels. He is seeking advice on whether high estrogen could be causing hair loss and how others with high estrogen levels have addressed it.

community If we lose hair because of our sensitivity to DHT, then why are we trying to reduce DHT when our sensitive androgen receptors are the culprit?

13 upvotes 4 years ago

The conversation discusses the effectiveness of reducing DHT for hair loss treatment and explores alternative approaches like reducing androgen receptor sensitivity. Specific treatments mentioned include finasteride, dutasteride, pyrilutamide (KX-826), GT20029, and RU58841.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

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Learn

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learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

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