Hair Follicle Regeneration Using Grafted Rodent and Human Cells

April 2007 in “ Journal of Investigative Dermatology ”

Ritsuko Ehama, Yumiko Ishimatsu-Tsuji, Shunsuke Iriyama, Ritsuro Ideta, Tsutomu Soma, Kiichiro Yano, Chikako Kawasaki, Satoshi O. Suzuki, Yuji Shirakata, Koji Hashimoto, Jiro Kishimoto

hair follicle regeneration grafted rodent cells grafted human cells human keratinocytes murine mesenchymal cells epithelial-mesenchymal interaction glabrous skin follicular epithelia adult epidermis chimeric hair follicle-like structures undifferentiated stem-like cells follicular epithelium culture conditions inductive property grafted cells keratinocytes mesenchymal cells stem cells skin cells

Studysummary In this study, co-grafting human keratinocytes with murine dermal papilla-enriched cells produced hair follicle-like structures, but without regular hair formation, suggesting anomalous folliculogenesis.

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854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

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This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.