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    The Role of Smads in Skin Development

    March 2008 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    P. C. Owens, Gangwen Han, Allen G. Li, Xiaojing Wang
    Studysummary This review examines the roles of Smad-4 and Smad-7 in hair follicle differentiation and development through BMP signaling and TGFβ/Activin/BMP pathway inhibition but reports no new experimental results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes Proceedings of the National Academy of Sciences of the United States of America · 2006
    2. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006
    3. Smad7-Induced Beta-Catenin Degradation Alters Epidermal Appendage Development Developmental Cell · 2006
    4. Stem Cells and Their Niches Science · 2006
    5. Runx3 Is Involved in Hair Shape Determination Developmental dynamics · 2005
    6. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    7. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    8. Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin The FASEB Journal · 2003
    9. Overexpression of Smad7 Results in Severe Pathological Alterations in Multiple Epithelial Tissues The EMBO Journal · 2002
    10. Bone Morphogenetic Protein-2 Transactivates Dlx3 Through Smad1 and Smad4: Alternative Mode for Dlx3 Induction in Mouse Keratinocytes Nucleic Acids Research · 2002
    11. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001