Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion

Delta1 is crucial for controlling skin cell growth and preventing tumors in mice.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

This article reviews the biology of epithelial stem cells and their role in tissue self-renewal, maintenance, and regeneration, and it highlights the clinical implications of understanding their signaling pathways, but it presents no new clinical findings.

This study reports that activating Notch signaling in the hair follicle cortex of transgenic mice caused abnormal differentiation of the medulla and cuticle, highlighting potential cell-cell interactions.

This study found that Notch-related genes, including Notch1 and Notch2, and their ligands and regulators, have distinct patterns of expression during mouse hair vibrissa follicle development and the adult hair cycle.

This study suggests that mNotch expression plays a significant role in hair follicle differentiation and cell fate selection within the follicle during development.