Trypsin-induced follicular papilla apoptosis results in delayed hair growth and pigmentation

The study demonstrated that trypsin, a serine protease, induced apoptosis in the follicular papilla of a synchronized hair growth mouse model, leading to delayed hair growth and pigmentation. This suggested that trypsin might influence a receptor-mediated signaling pathway responsible for cell death in the follicular papilla. The findings highlighted the role of proteases in programmed cell death, which is crucial for development and homeostasis.