Comparative Study of a Topical and Oral Combination Therapy Containing Oleanolic Acid, Apigenin, and Biotinyl Tripeptide-1 in Patients with Androgenetic Alopecia: A Prospective, Open-Label Trial

    July 2025 in “ Cosmetics ”
    Vlad-Mihai Voiculescu, Mihai Lupu
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    TLDR The combination therapy improved hair growth and thickness in people with androgenetic alopecia.
    This study evaluated the efficacy of a combination therapy containing oleanolic acid, apigenin, and biotinyl tripeptide-1 in treating androgenetic alopecia (AGA) over 3 months, involving 48 participants. Participants were divided into two groups: one using only a topical spray and the other using both the spray and oral capsules. Results showed significant improvements in hair density, hair shaft thickness, and anagen/telogen ratio in both groups, with the combination therapy group showing more pronounced effects. The study suggests that this combination therapy could be a promising alternative for AGA management, though long-term effects require further investigation.
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