Comparative Study of a Topical and Oral Combination Therapy Containing Oleanolic Acid, Apigenin, and Biotinyl Tripeptide-1 in Patients with Androgenetic Alopecia: A Prospective, Open-Label Trial

    July 2025 in “ Cosmetics ”
    Vlad-Mihai Voiculescu, Mihai Lupu
    Studysummary This study found that a combination of topical and oral treatment led to greater improvements in hair density, thickness, and anagen/telogen ratio in patients with androgenetic alopecia compared to topical treatment alone, with significant benefits observed over a 3-month period.
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    Research cited in this study 19

    1. Randomized Clinical Trial to Evaluate the Effect of Probiotic Intake on Androgenic Alopecia Nutrients · 2024
    2. The Comparison of Metabolic Syndrome Parameters, Trichoscopic and Trichoscan Characteristics in Androgenetic Alopecia (AGA) and Early-Onset Androgenetic Alopecia (Early-Onset AGA) Archives of Dermatological Research · 2024
    3. Trichoscopy of Androgenetic Alopecia: A Systematic Review Journal of clinical medicine · 2024
    4. Short-Term Clinical Assessment of Treating Female Androgenic Alopecia with Autologous Stem Cells Derived from Human Hair Follicles Biomedicines · 2024
    5. Efficacy of Topical Minoxidil and Finasteride Association Compared to Monotherapy in Men With Androgenetic Alopecia: A Prospective, Randomized, Controlled, Assessor-Blinded, 3-Arm, Pilot Trial Journal of Cosmetic Dermatology · 2023
    6. An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing the Big Eight Strikes Cosmetics · 2023
    7. Effects of Oleanolic Acid on Hair Growth in Mouse Dorsal Skin Mediated via Regulation of Inflammatory Cytokines Journal of Applied Biomedicine · 2023
    8. Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia International Journal of Molecular Sciences · 2020
    9. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    10. Efficacy and Safety of a New Topical Hair Loss Lotion Containing Oleanolic Acid, Apigenin, Biotinyl Tripeptide-1, Diaminopyrimidine Oxide, Adenosine, Biotin, and Ginkgo Biloba in Patients with Androgenetic Alopecia and Telogen Effluvium: A Six-Month Open-Label Prospective Clinical Study Journal of cosmetology & trichology · 2018
    11. Beta-Catenin Is Involved in Oleanolic Acid-Dependent Promotion of Proliferation in Human Hair Matrix Cells in an In Vitro Organ Culture Model Fitoterapia · 2017
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    13. Nutrition and Hair: The Role of Nutrients in Hair Health Dermatologic Clinics · 2012
    14. S1 Guideline for Diagnostic Evaluation in Androgenetic Alopecia in Men, Women, and Adolescents British Journal of Dermatology · 2010
    15. A Cell-Based System for Screening Hair Growth-Promoting Agents Archives of Dermatological Research · 2009
    16. Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial Journal of Dermatology · 2008
    17. Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations British Journal of Dermatology · 2006
    18. TrichoScan: A Novel Tool for the Analysis of Hair Growth In Vivo Journal of Investigative Dermatology Symposium Proceedings · 2003
    19. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002