The TNFRSF1B Connection: Implications For Androgenetic Alopecia Pathogenesis And Treatment

This study explores the role of the TNFRSF1B gene in androgenetic alopecia (AGA), identifying it as a potential pathogenic factor and therapeutic target. Using transcriptomic data and various analyses, the researchers found significant upregulation of TNFRSF1B in AGA patient hair follicles. Mendelian randomization confirmed a causal relationship between TNFRSF1B and AGA. In vitro experiments showed that TNFRSF1B knockdown enhanced hair dermal papilla cell proliferation and migration, reduced apoptosis, and alleviated oxidative stress. In vivo, TNFRSF1B knockdown promoted hair regeneration in an AGA mouse model. These findings suggest that targeting TNFRSF1B could be a novel approach for AGA treatment.