The effect of tripeptide-copper complex on human hair growth in vitro
July 2007
in “Archives of Pharmacal Research”
TLDR A tripeptide-copper complex may help hair grow by increasing cell growth and decreasing cell death.
The study from 2007 found that a tripeptide-copper complex, AHK-Cu, stimulated the elongation of human hair follicles and the proliferation of dermal papilla cells (DPCs) at concentrations between 10^-12 and 10^-9 M. The research involved 240 hair follicles from three volunteers and showed that while AHK-Cu at 10^-9 M did not significantly reduce the number of apoptotic DPCs, it did increase the Bcl-2/Bax ratio and decreased levels of apoptosis markers caspase-3 and PARP. These findings suggest that AHK-Cu may promote hair growth by stimulating DPC proliferation and preventing apoptosis, indicating its potential as a therapeutic agent for hair growth promotion.
View this study on link.springer.com →
Cited in this study
research Reorganization of hair follicles in human skin organ culture induced by cultured human follicle-derived cells
Injected human hair follicle cells can create new, small hair follicles in skin cultures.
research Limitations of human occipital scalp hair follicle organ culture for studying the effects of minoxidil as a hair growth enhancer
Scalp hair follicle culture has limits for testing minoxidil's hair growth effects.
research Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle
Minoxidil boosts hair growth by increasing cell production and survival.
research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia
TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.
research Hair keratin pattern in human hair follicles grown in vitro
research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle
Finasteride affects hair growth by changing caspase and XIAP levels, potentially treating hair diseases.
research Control of hair growth and follicle size by VEGF-mediated angiogenesis
VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
research Role of hair papilla cells on induction and regeneration processes of hair follicles
Hair papilla cells can create and regenerate hair bulbs under the right conditions.
research Whole Hair Follicle Culture
Related
research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes
Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
research A model system to analyse the ability of human keratinocytes to form hair follicles
Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
research Review of hair follicle dermal cells
Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
research STUDY ON HAIR FOLLICLE FORMATION INDUED BY DERAMAL PAPILLA CELL
research Trans‐species hair growth induction by human hair follicle dermal papillae
Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
research Role of hair papilla cells on induction and regeneration processes of hair follicles
Hair papilla cells can create and regenerate hair bulbs under the right conditions.