The effect of tripeptide-copper complex on human hair growth in vitro

    July 2007 in “Archives of Pharmacal Research
    Hyun Keol Pyo, Hyeon Gyeong Yoo, Chong Hyun Won, Seung Ho Lee, Yong‐Kook Kang, Hee Chul Eun, Kwang Hyun Cho, Kyu Han Kim
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    TLDR A tripeptide-copper complex may help hair grow by increasing cell growth and decreasing cell death.
    The study from 2007 found that a tripeptide-copper complex, AHK-Cu, stimulated the elongation of human hair follicles and the proliferation of dermal papilla cells (DPCs) at concentrations between 10^-12 and 10^-9 M. The research involved 240 hair follicles from three volunteers and showed that while AHK-Cu at 10^-9 M did not significantly reduce the number of apoptotic DPCs, it did increase the Bcl-2/Bax ratio and decreased levels of apoptosis markers caspase-3 and PARP. These findings suggest that AHK-Cu may promote hair growth by stimulating DPC proliferation and preventing apoptosis, indicating its potential as a therapeutic agent for hair growth promotion.
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