The Determination of the Stability Constant of Finasteride Complexes with Various Metals by Potentiometric and Spectrophotometric Methods

May 2016 in “ Marmara Pharmaceutical Journal ”

Aysen Kurt Cucu, Emine Arslan, Serap Karaderi

finasteride cobalt(II) zinc(II) cadmium(II) copper(II) potentiometric methods spectrophotometric methods protonation constant stability constants Propecia

TLDR Finasteride forms stable complexes with cobalt, zinc, cadmium, and copper.

The study determined the stability constants of finasteride complexes with cobalt(II), zinc(II), cadmium(II), and copper(II) using potentiometric methods (Irving-Rossotti and Calvin-Bjerrum) and supported by spectrophotometric methods. The protonation constant of finasteride was logK=2.21. The stability constants for the metal complexes were logK=3.01 for cobalt(II), logK=2.82 for zinc(II), logK=3.04 for cadmium(II), and logK=2.85 for copper(II) at 25°C. These findings, supported by spectrometric measurements, indicated the formation of complexes and could aid in analyzing blood samples, as these metals can enter the human body.

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