Skin Cancer Risk in Alopecia Areata: A Systematic Review and Meta-Analysis

    May 2026 in “ Frontiers in Oncology ”
    Simonetta I. Gaumond, Alireza Abdshah, Isabella Kamholtz … JJ Jimenez
    Studysummary In this study, alopecia areata was associated with a statistically significant reduction in melanoma incidence, but not in overall skin cancer risk, highlighting the need for cautious interpretation due to heterogeneity.
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    Research cited in this study 10

    1. Evaluating Current and Emerging JAK Inhibitors for Alopecia Areata: A Narrative Review Dermatology and Therapy · 2025
    2. Rates of Infections, Malignancies, Cardiovascular Outcomes, and Death in Individuals with Hospital-Treated Alopecia Areata: A Registry-Based Cohort Study in Denmark Acta Dermato Venereologica · 2025
    3. IL-15 in T-Cell Responses and Immunopathogenesis Immune Network · 2024
    4. Treatments for Moderate-to-Severe Alopecia Areata: A Systematic Narrative Review Dermatology and therapy · 2023
    5. Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database Dermatology and therapy · 2023
    6. A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021
    7. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    8. Cancer Risk by the Subtype of Alopecia Scientific Reports · 2018
    9. Cancer Risk in Patients with Alopecia Areata: A Nationwide Population-Based Matched Cohort Study Cancer Medicine · 2018
    10. Alopecia Areata: What’s New in Epidemiology, Pathogenesis, Diagnosis, and Therapeutic Options? Journal of dermatological science · 2016