Effect of Rubbing on the Distribution of Topically Applied Drugs into the Hair Follicles

    August 2020 in “ Chemical and Pharmaceutical Bulletin ”
    Akinari Abe, Hiromichi Suzuki, Miyuki Saito … Kenji Sugibayashi
    Studysummary This study found that rubbing increased caffeine permeation into skin primarily via hair follicles, especially when applied against the natural hair direction.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 6

    1. Establishment of an Evaluation Method to Detect Drug Distribution in Hair Follicles International Journal of Pharmaceutics · 2018
    2. Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2011
    3. Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam European Journal of Pharmaceutics and Biopharmaceutics · 2010
    4. Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2009
    5. Follicular Transport Route: Research Progress and Future Perspectives European journal of pharmaceutics and biopharmaceutics · 2009
    6. Variations of Hair Follicle Size and Distribution in Different Body Sites Journal of Investigative Dermatology · 2004