Rapid Determination of Finasteride in Human Plasma by UPLC-MS/MS and Its Application to Clinical Pharmacokinetic Study

    June 2010 in “ Journal of Chromatography B ”
    Panagiotis L. Kastritis, Hae Young Lee, Mi-sun Lim, Eun-Hee Kim, Sung-Doo Kim, Jeonghyeon Park, Miran Lee, Sung-Kyu Hwang, Young-Ran Yoon
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    TLDR New method measures finasteride in blood quickly and accurately.
    The paper describes a validated UPLC-MS/MS method for quantifying finasteride in human plasma, with a linear response from 0.1 to 30 ng/mL and a limit of quantitation of 0.1 ng/mL. The method was successfully applied to a pharmacokinetic study of finasteride in healthy volunteers following oral administration. The UPLC-MS/MS method described herein boasts significant advantages over other techniques, including LC-MS/MS, due to the inherently increased column efficiency of UPLC, which resulted in complete analysis within 3.5 min with significantly lower limits of quantitation (0.1 ng/mL).
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