Platelet-rich plasma as a potential treatment for noncicatricial alopecias

    Gkini Maria-Angeliki, Kouskoukis Alexandros-Efstratios, Rigopoulos Dimitris, Kouskoukis Konstantinos
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    TLDR Platelet-rich plasma, which carries growth factors, could be a promising treatment for non-scarring hair loss, promoting hair growth and density with no major side effects.
    Eight years ago, a systematic review of 14 articles suggested that platelet-rich plasma (PRP), an autologous concentration of platelets in concentrated plasma carrying over 20 growth factors, could be a promising treatment for noncicatricial alopecias, including androgenetic alopecia (AGA) and alopecia areata (AA). The growth factors in PRP were found to promote inflammation, cell proliferation, differentiation, and regeneration in the hair follicle, thereby promoting hair growth. Several studies reported significant increases in hair density and regrowth after PRP treatment, with no major adverse effects. However, due to small sample sizes and lack of controls in these studies, further investigation was needed to confirm the efficacy and safety of PRP. Additionally, there was no consensus on the exact concentration, dosing parameters, and depth of PRP injections, as well as the frequency and number of required sessions.
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