Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge
March 2009
in “
Experimental Dermatology
”
pilomatricoma hair matrix hair cortex follicular infundibulum outer root sheath hair bulge immunohistochemical analysis anti-keratin antibodies anti-filaggrin antibody basophilic cells transitional cells shadow cells infundibular-type epithelium K1 K10 filaggrin trichilemmal keratinization K14 K16 K19
The study on pilomatricoma, involving 53 cases, revealed that this condition could differentiate not only towards the hair matrix and hair cortex but also towards the follicular infundibulum, outer root sheath, and hair bulge. The research utilized immunohistochemical analysis with 10 monospecific anti-keratin antibodies and anti-filaggrin antibody. It was found that basophilic, transitional, and shadow cells did not react with these antibodies, unlike the infundibular-type epithelium, which was positive for K1, K10, and filaggrin. Additionally, trichilemmal keratinization showed positivity for K14 and K16, while hair bulge-like structures were positive for K19. This indicated a heterogeneous pattern of differentiation in pilomatricoma.
