Functional Analysis of Keratin Components in the Mouse Hair Follicle Inner Root Sheath

February 2004 in “ British Journal of Dermatology ”

Rebecca M. Porter, M. V. Gandhi, N.J. Wilson, Pamela Wood, W.H. Irwin McLean, E. Birgitte Lane

TLDR Keratin in mouse hair follicles is complex and plays specific roles.

The study provided evidence of the complexity of keratin expression within the three concentric layers of the inner root sheath in mouse hair follicles. This research contributed to the understanding of the specific roles and interactions of keratin components in hair follicle structure and function, highlighting the intricate nature of keratin expression patterns in these layers.

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Research cited in this study

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research K6irs1, K6irs2, K6irs3, And K6irs4 Represent The Inner-Root-Sheath-Specific Type II Epithelial Keratins Of The Human Hair Follicle

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A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.

research Keratin K6irs Is Specific to the Inner Root Sheath of Hair Follicles in Mice and Humans

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Keratin K6irs is a marker for the inner root sheath of hair follicles in mice and humans.

research The Catalog of Human Hair Keratins

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research Discovery of a Novel Murine Keratin 6 (K6) Isoform Explains the Absence of Hair and Nail Defects in Mice Deficient for K6a and K6b

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research A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

45 citations , March 2001 in “Journal of Investigative Dermatology”

A new protein, mK6irs, is found in specific hair layers and may help understand hair growth and diseases.

research A Unique Type I Keratin Intermediate Filament Gene Family Is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles

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research The Mouse Keratin 6 Isoforms Are Differentially Expressed in the Hair Follicle, Footpad, Tongue, and Activated Epidermis

75 citations , October 1999 in “Differentiation”

Mouse keratin 6 isoforms have different expression patterns in various tissues.

research The Catalog of Human Hair Keratins

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Human hair is made up of different keratins, some strong and some weak, with specific types appearing at various stages of hair growth.

research WNT Signaling in the Control of Hair Growth and Structure

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research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

139 citations , December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

K6hf is a unique protein found only in a specific layer of hair follicles.

research CDNA Cloning, Expression, And Assembly Characteristics Of Mouse Keratin 16

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Mouse and human keratin 16 can both form filaments, with differences likely due to the tail domain, not the helical domain.

research A Splice Site Mutation in the Human Type I Hair Keratin Gene hHa1 Results in the Expression of a Tailless Keratin Isoform

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research The Fate of Trichohyalin

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research Characterization of LHTric-1: A New Monospecific Monoclonal Antibody to Trichocyte Keratin Ha1

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LHTric-1 is a specific antibody useful for studying hair and nail formation.

research Assembly of Hair Keratins in Transfected Epithelial Cells

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Mouse hair keratins mHa1 and mHb4 can't form a strong network on their own in cells.

research Disorders of Hair Growth: Diagnosis and Treatment

November 1994 in “JAMA”

The book is a detailed guide on hair growth issues and treatments, recommended for specialists and hospital libraries.

research Structural Features and Sites of Expression of a New Murine 65 kD and 48 kD Hair-Related Keratin Pair, Associated with a Special Type of Parakeratotic Epithelial Differentiation

28 citations , August 1992 in “Differentiation”

A new pair of mouse keratins, 65 kD and 48 kD, are found in specific skin areas and are linked to a unique skin differentiation type.

research Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins

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Keratin expression reflects cell organization and differentiation, not causes it.

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles

248 citations , April 1988 in “Differentiation”

Human and bovine hair follicles have distinct cytokeratins specific to hair-forming cells.

research Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro

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Outer root sheath cells consistently express certain keratins influenced by their environment.

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

research Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle

116 citations , April 1986 in “The journal of cell biology/The Journal of cell biology”

Trichohyalin is a protein in hair follicles that helps form hair filaments.

research Structural Features of the Alpha-Type Filaments of the Inner Root Sheath Cells of the Guinea Pig Hair Follicle

24 citations , November 1978 in “Biochemistry”

α-type filaments in guinea pig hair follicles have unique structural features.

Related Research

1 / 1 results

research Functional Analysis of Keratin Components in the Mouse Hair Follicle Inner Root Sheath

23 citations , February 2004 in “British Journal of Dermatology”

Keratin in mouse hair follicles is complex and plays specific roles.

Functional Analysis of Keratin Components in the Mouse Hair Follicle Inner Root Sheath

Research cited in this study

research K6irs1, K6irs2, K6irs3, And K6irs4 Represent The Inner-Root-Sheath-Specific Type II Epithelial Keratins Of The Human Hair Follicle

research Cloning of Human, Murine, and Marsupial Keratin 7 and a Survey of K7 Expression in the Mouse

research A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle

research Keratin K6irs Is Specific to the Inner Root Sheath of Hair Follicles in Mice and Humans

research The Catalog of Human Hair Keratins

research Discovery of a Novel Murine Keratin 6 (K6) Isoform Explains the Absence of Hair and Nail Defects in Mice Deficient for K6a and K6b

research A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

research A Unique Type I Keratin Intermediate Filament Gene Family Is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles

research The Mouse Keratin 6 Isoforms Are Differentially Expressed in the Hair Follicle, Footpad, Tongue, and Activated Epidermis

research The Catalog of Human Hair Keratins

research WNT Signaling in the Control of Hair Growth and Structure

research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

research CDNA Cloning, Expression, And Assembly Characteristics Of Mouse Keratin 16

research A Splice Site Mutation in the Human Type I Hair Keratin Gene hHa1 Results in the Expression of a Tailless Keratin Isoform

research The Fate of Trichohyalin

research Characterization of LHTric-1: A New Monospecific Monoclonal Antibody to Trichocyte Keratin Ha1

research Assembly of Hair Keratins in Transfected Epithelial Cells

research Disorders of Hair Growth: Diagnosis and Treatment

research Structural Features and Sites of Expression of a New Murine 65 kD and 48 kD Hair-Related Keratin Pair, Associated with a Special Type of Parakeratotic Epithelial Differentiation

research Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins

research A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles

research Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle

research Structural Features of the Alpha-Type Filaments of the Inner Root Sheath Cells of the Guinea Pig Hair Follicle

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