Keratin K6irs Is Specific to the Inner Root Sheath of Hair Follicles in Mice and Humans

October 2001 in “ British Journal of Dermatology ”

Rebecca M. Porter, Laura D. Corden, Declan P. Lunny, Francis J. Smith, E. Birgitte Lane, W.H. Irwin McLean

keratin K6irs inner root sheath hair follicles loose anagen syndrome inherited structural hair defects

TLDR Keratin K6irs is a marker for the inner root sheath of hair follicles in mice and humans.

The study identified a new keratin, K6irs, which served as a specific histological marker for the inner root sheath of hair follicles in both mice and humans. This discovery was significant as it provided a potential candidate gene for investigating inherited structural hair defects, including conditions like loose anagen syndrome.

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Research cited in this study

8 / 8 results

research A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

45 citations , March 2001 in “Journal of Investigative Dermatology”

A new protein, mK6irs, is found in specific hair layers and may help understand hair growth and diseases.

research A Unique Type I Keratin Intermediate Filament Gene Family Is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles

41 citations , January 2001 in “Journal of Investigative Dermatology”

research Expression of MK6a Dominant-Negative and C-Terminal Mutant Transgenes in Mice Has Distinct Phenotypic Consequences in the Epidermis and Hair Follicle

30 citations , October 1999 in “Differentiation”

Mutant MK6a transgenes in mice cause blistering, hair loss, and potential human alopecia.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

research Ontogeny and Regional Variability of Keratin 2e in Developing Human Fetal Skin: A Unique Spatial and Temporal Pattern of Keratin Expression in Development

19 citations , April 1999 in “British Journal of Dermatology”

Keratin 2e shows a unique pattern in developing fetal skin, different from other keratins.

research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

139 citations , December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

K6hf is a unique protein found only in a specific layer of hair follicles.

research Loose Anagen Hair

24 citations , September 1997 in “PubMed”

Loose anagen hair can appear at any age and may improve over time.

research Organization and Expression of Hair Follicle Genes

48 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair growth is controlled by specific gene clusters and proteins, and cysteine affects hair gene expression in sheep.

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research Hair Keratin Pattern in Human Hair Follicles Grown In Vitro

29 citations , April 2003 in “Experimental dermatology”

Human hair follicles grown in vitro maintain normal keratin patterns and structure.

research Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments

686 citations , February 2002 in “Current Opinion in Cell Biology”

Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.

Keratin K6irs Is Specific to the Inner Root Sheath of Hair Follicles in Mice and Humans

Research cited in this study

research A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

research A Unique Type I Keratin Intermediate Filament Gene Family Is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles

research Expression of MK6a Dominant-Negative and C-Terminal Mutant Transgenes in Mice Has Distinct Phenotypic Consequences in the Epidermis and Hair Follicle

research The Biology of Hair Follicles

research Ontogeny and Regional Variability of Keratin 2e in Developing Human Fetal Skin: A Unique Spatial and Temporal Pattern of Keratin Expression in Development

research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

research Loose Anagen Hair

research Organization and Expression of Hair Follicle Genes

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research Hair Keratin Pattern in Human Hair Follicles Grown In Vitro

research Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments