Partial Alopecia Area Retains Bulge Hair Follicle Progenitor Cells in Indian Androgenetic Alopecia Patients

    September 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Akshay Hegde, Dyuti Saha, Savitha Somaiah, Colin Jamora
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    TLDR Some hair growth cells remain in partially bald areas of Indian men with hair loss.
    The study "Partial alopecia area retains bulge hair follicle progenitor cells in Indian androgenetic alopecia patients" investigates the progression of Androgenic alopecia (AGA), a condition characterized by a progressive decrease in scalp hair follicle density. The research reveals that completely bald areas in AGA patients still retain hair follicle stem cells, but the progenitor cells are significantly reduced. The study further observes that partially bald areas retain progenitor cells expressing CD34 and Sox9, which are absent in completely bald areas. This research is particularly significant as it provides insights into the timeframe for effective therapeutic interventions aimed at reactivating the existing inactive follicle stem cells, especially in the Indian male population where AGA prevalence is 58%.
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