The Role Of Oral Supplements In Mitigating Common Isotretinoin Side Effects: A Comprehensive Review

December 2025 in “ International Journal of Innovative Technologies in Social Science ”

Maria Gierasimiuk, Adam Januszkiewicz, Wiktoria Januszkiewicz, Wojciech Machulski, Martyna Ciarkowska, Jan Krzysztof Makulski, Kamil Franczyk, K. Świerk, Damian Podkościelny, Michal Gorski

isotretinoin acne vulgaris Vitamin E Vitamin D Omega-3 fatty acids Folic Acid Vitamin B12 Biotin Accutane fish oil

TLDR Oral supplements like Vitamin E and Omega-3 can help reduce isotretinoin side effects.

This review explores the potential of oral supplements to reduce side effects of isotretinoin, a treatment for acne vulgaris. It assesses supplements like Vitamin E, Vitamin D, Omega-3 fatty acids, Folic Acid, Vitamin B12, and Biotin for their effectiveness in alleviating these adverse effects. The goal is to offer evidence-based recommendations to help clinicians and patients enhance treatment tolerability by using these supplements alongside isotretinoin.

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