The Role Of Oral Supplements In Mitigating Common Isotretinoin Side Effects: A Comprehensive Review

December 2025 in “ International Journal of Innovative Technologies in Social Science ”

Maria Gierasimiuk, Adam Januszkiewicz, Wiktoria Januszkiewicz, Wojciech Machulski, Martyna Ciarkowska, Jan Krzysztof Makulski, Kamil Franczyk, K. Świerk, Damian Podkościelny, Michal Gorski

isotretinoin acne vulgaris Vitamin E Vitamin D Omega-3 fatty acids Folic Acid Vitamin B12 Biotin Accutane fish oil

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vitamin you should probably be taking for general health might also help your hair a little

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Studysummary This narrative review assesses evidence on the role of oral supplements in reducing common side effects caused by isotretinoin treatment for acne vulgaris, with the aim of providing guidance for enhancing treatment tolerability. Our plain-language summary of this paper — not a Tressless recommendation.

This review explores the potential of oral supplements to reduce side effects of isotretinoin, a treatment for acne vulgaris. It assesses supplements like Vitamin E, Vitamin D, Omega-3 fatty acids, Folic Acid, Vitamin B12, and Biotin for their effectiveness in alleviating these adverse effects. The goal is to offer evidence-based recommendations to help clinicians and patients enhance treatment tolerability by using these supplements alongside isotretinoin.

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research Isotretinoin and Hair Loss: A Clinical Perspective and Literature Review

September 2025 in “SKIN The Journal of Cutaneous Medicine”

This study reports a case of alopecia areata in a 14-year-old male using isotretinoin for acne, illustrating an unexpected side effect not typically linked to the drug, highlighting the importance of monitoring and addressing hair loss risks during treatment.

research Vitamin B-Complex and Its Relationship With the Health of Vegetarian People

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This paper offers a detailed overview of B vitamins, detailing their importance for energy, cognition, and metabolism, conditions leading to their deficiencies, symptoms of deficiencies, and the foods rich in these essential nutrients.

research Adverse Events in Isotretinoin Therapy: A Single-Arm Meta-Analysis

7 citations , May 2022 in “International Journal of Environmental Research and Public Health”

This study found that isotretinoin therapy for acne vulgaris typically causes mild mucocutaneous adverse events, which are reversible and vary individually.

Evaluation of Biophysical Skin Parameters and Hair Changes in Patients with Acne Vulgaris Treated with Isotretinoin, and the Effect of Biotin Use on These Parameters

research Evaluation of Biophysical Skin Parameters and Hair Changes in Patients with Acne Vulgaris Treated with Isotretinoin, and the Effect of Biotin Use on These Parameters

5 citations , March 2021 in “International Journal of Dermatology”

This study found that adding 10 mg/day of biotin to isotretinoin treatment for acne improved hair growth and maintained skin hydration, potentially reducing isotretinoin's mucocutaneous side effects.

Is the Effect Worth the Risk? The Most Common Complaints During Oral Isotretinoin Anti-Acne Therapy and Controversies Around Its Adverse Effects

research Is the Effect Worth the Risk? The Most Common Complaints During Oral Isotretinoin Anti-Acne Therapy and Controversies Around Its Adverse Effects

September 2020 in “Journal of Education, Health and Sport”

In this study, common side effects of isotretinoin, including dry lips, mucous membrane dryness, tiredness, and mood changes, were frequently reported among Polish patients, though their severity was usually mild.

research The Role of Vitamins and Minerals in Hair Loss: A Review

134 citations , December 2018 in “Dermatology and Therapy”

This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.

research Curling of Hair in Two Female Patients Taking Alitretinoin

6 citations , October 2018 in “Drug safety - case reports”

In this report, two women treated with alitretinoin experienced persistent curling of their previously straight hair, suggesting a likely causal link between the medication and hair texture changes.