Acne-Associated Syndromes

January 2019 in “ Springer eBooks ”

Gerd Plewig, Bodo C. Melnik, WenChieh Chen

Studysummary Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Prolactin as a Candidate Sebotropic Hormone?

26 citations , March 2018 in “Experimental Dermatology”

This article argues that prolactin may have a role in sebaceous gland function and suggests it could be a potential target for treating skin conditions, but reports no new clinical findings.

research Acanthosis Nigricans and the Metabolic Syndrome

30 citations , September 2017 in “Clinics in Dermatology”

This article reviews the clinical and histological features of acanthosis nigricans and its associations with insulin resistance and other conditions, but highlights the need for more research on its classification, severity assessment, and treatment options.

research History of Discovery of Polycystic Ovary Syndrome

22 citations , June 2017 in “Advances in Clinical and Experimental Medicine”

This review discusses the historical understanding and evolving diagnostic criteria for polycystic ovary syndrome without presenting new clinical findings, highlighting the multifactorial nature and associated risks of the condition.

Non-Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Revisited: An Update with a Special Focus on Adolescent and Adult Women

research Non-Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Revisited: An Update with a Special Focus on Adolescent and Adult Women

117 citations , May 2017 in “Human Reproduction Update”

This review examines the epidemiology, pathophysiology, diagnosis, and management strategies for non-classic congenital hyperplasia due to 21-hydroxylase deficiency, and provides evidence-based recommendations for its treatment and genetic counseling.

research Congenital Adrenal Hyperplasia: A Comprehensive Review

88 citations , April 2017 in “Journal of Pediatric and Adolescent Gynecology”

This review discusses the pathophysiology, diagnosis, and treatment of congenital adrenal hyperplasia, but reports no new research results.

research Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ

76 citations , October 2016 in “Clinics in dermatology”

This review discusses the hormonal and genetic factors influencing acne development, emphasizing the role of androgens and insulin signaling but reports no new clinical results.

research Difficult and Rare Forms of Acne

18 citations , October 2016 in “Clinics in Dermatology”

This review discusses the challenges and complexities in diagnosing and managing acne and reports no new clinical findings; it emphasizes the need for careful evaluation to distinguish difficult acne from similar conditions.

American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

research American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

343 citations , October 2015 in “Endocrine Practice”

This review discusses the diagnostic criteria and management strategies for Polycystic Ovary Syndrome (PCOS) and highlights the need for comprehensive clinical assessment, but does not report new clinical findings.

research Linking Diet to Acne Metabolomics, Inflammation, and Comedogenesis: An Update

138 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

This review discusses how Western diet may contribute to acne vulgaris through insulin signaling and metabolomic changes, promoting a dietary approach for management, but reports no new experimental results.

research Cardiovascular Risk Factors and Events in Women with Androgen Excess

31 citations , November 2014 in “Journal of Endocrinological Investigation”

This article reviews androgen excess and cardiometabolic risks in women, highlighting increased cardiovascular disease risk in those with polycystic ovary syndrome, but reports no new clinical results.

research Acne as a Chronic Systemic Disease

71 citations , November 2013 in “Clinics in Dermatology”

This review discusses the chronic nature of acne and its association with various systemic diseases, but reports no new clinical findings, highlighting the need for further study on its nutritional or genetic links.

research Non-Classic Congenital Adrenal Hyperplasia

42 citations , April 2013 in “Steroids”

This review discusses the pathophysiology, molecular genetics, and management of non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, with no new clinical findings reported.

research Acne-Associated Syndromes: Models for Better Understanding of Acne Pathogenesis

99 citations , December 2010 in “Journal of The European Academy of Dermatology and Venereology”

This article discusses the association of acne with various systemic diseases, emphasizing the role of androgen steroids, insulin resistance, and inflammation in acne pathogenesis, but it reports no new clinical results.

research Ovarian Morphology and Prevalence of Polycystic Ovary Syndrome in Reproductive Aged Women With or Without Mild Acne

20 citations , June 2010 in “International Journal of Dermatology”

In this study, acne and hirsutism in women were associated with a higher prevalence of polycystic ovary syndrome compared to those without these conditions.

research Anti-Androgen Treatments for Hirsutism and Acne in Women of Childbearing Age

24 citations , January 2010 in “Annales d'endocrinologie”

This review discusses treatment options for hirsutism in women of childbearing age, focusing on the use of contraceptives, CPA, spironolactone, and third-line therapies, and reports no clinical results.

research Role of FGFR2-Signaling in the Pathogenesis of Acne

63 citations , May 2009 in “Dermato-endocrinology”

This review explores the role of FGFR2b-signaling in the pathogenesis of acne, highlighting its influence on sebaceous gland physiology and the effects of anti-acne agents like isotretinoin.

research Hormones and the Pilosebaceous Unit

97 citations , March 2009 in “Dermato-endocrinology”

This review explores the role of hormones in pilosebaceous units and associated skin disorders, focusing on androgen action, without presenting new clinical findings.

research Congenital Adrenal Hyperplasia: A Review of 21-Hydroxylase Deficiency and Diagnostic Challenges

26 citations , March 2009 in “Dermato-endocrinology”

This review discusses the evaluation, clinical presentation, and cutaneous manifestations of congenital adrenal hyperplasia, focusing on differential diagnosis challenges with polycystic ovary syndrome, and reports no new clinical findings.

research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

65 citations , February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

This paper discusses the hypothesis that anti-acne agents may work by reducing FGFR2 signaling, and emphasizes FGFR2's potential role in acne pathogenesis, but it reports no new experimental findings.

research Androgen Dependence of Hirsutism, Acne, and Alopecia in Women

105 citations , January 2009 in “Medicine”

This study found that ethinylestradiol and high-dose cyproterone acetate significantly reduced hirsutism scores and were effective for treating acne and alopecia in women with hyperandrogenism.

A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia Among Women Presenting with Hyperandrogenic Symptoms and Signs

research A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia Among Women Presenting with Hyperandrogenic Symptoms and Signs

150 citations , November 2007 in “The Journal of Clinical Endocrinology and Metabolism”

This study determined that nonclassical congenital adrenal hyperplasia has a 2.2% prevalence among hyperandrogenic women in Spain, with basal serum 17-hydroxyprogesterone showing excellent diagnostic performance.

research Sexual Hormones in Human Skin

305 citations , February 2007 in “Hormone and metabolic research”

This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.

research Dermatology of Androgen-Related Disorders

67 citations , July 2006 in “Clinics in Dermatology”

This review discusses the dermatologic manifestations of hyperandrogenism in women and outlines the diagnostic approach and treatment options, reporting no new clinical results.

research Relative Prevalence of Different Androgen Excess Disorders in 950 Women Referred Because of Clinical Hyperandrogenism

352 citations , January 2006 in “The Journal of Clinical Endocrinology and Metabolism”

This study reported that classic anovulatory PCOS was the most common androgen excess disorder, followed by mild ovulatory PCOS and idiopathic hyperandrogenism, among patients evaluated for clinical hyperandrogenism.

research Clinical Profiles, Occurrence, and Management of Adolescent Patients with HAIR-AN Syndrome

24 citations , January 2004 in “The scientific world journal/TheScientificWorldjournal”

This study found that HAIR-AN syndrome is prevalent among young women, and a multifaceted treatment approach effectively reduces symptom severity and prevents further consequences.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)

4025 citations , December 2003 in “Human Reproduction”

This review discusses the evolution of diagnostic criteria for polycystic ovary syndrome and emphasizes its association with various metabolic and cardiovascular risks, but it provides no new research findings.

research Successful Treatment of Hirsutism in HAIR-AN Syndrome Using Flutamide, Spironolactone, and Birth Control Therapy

17 citations , April 1997 in “Archives of dermatology”

This case report describes the treatment of hirsutism in a 15-year-old obese Mexican girl with flutamide, aiming to improve her social function.