Keratinocyte Differentiation in Psoriatic Scalp: Morphology and Expression of Epithelial Keratins

July 2006 in “ British Journal of Dermatology ”

Caroline Wilson, D. Dean, E. Birgitte Lane, R.P. RDAWBER, Irene M. Leigh

Studysummary This study found that keratin K17 is induced in the suprabasal layer of psoriatic scalp epidermis during epidermal hyperproliferation, suggesting it is not specific to hair follicles.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.

research Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins

238 citations , May 1989 in “Journal of Investigative Dermatology”

A Morphometric and Histologic Study of the Scalp in Psoriasis: Paradoxical Sebaceous Gland Atrophy and Decreased Hair Shaft Diameters Without Alopecia

research A Morphometric and Histologic Study of the Scalp in Psoriasis: Paradoxical Sebaceous Gland Atrophy and Decreased Hair Shaft Diameters Without Alopecia

15 citations , May 1989 in “PubMed”

This study found that in patch- and plaque-stage scalp psoriasis, sebaceous gland atrophy and reduced hair follicle size were common but there was no evidence of alopecia.

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues

124 citations , December 1988 in “Differentiation”

This study found that T cytokeratins appear more gradually and with complex coexpression patterns in developing nail structures compared to the more abrupt transition in hair follicles.

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles

248 citations , April 1988 in “Differentiation”

In this study, researchers observed that trichocytic and epithelial cytokeratins have distinct expression patterns within various human and bovine hair follicle cells, contributing to understanding hair follicle development and growth.

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.

research The Complement of Native Alpha-Keratin Polypeptides of Hair-Forming Cells: A Subset of Eight Polypeptides That Differ from Epithelial Cytokeratins

198 citations , October 1986 in “Differentiation”

research The In Vitro Properties of Dermal Papilla Cell Lines Established From Human Hair Follicles

106 citations , April 1986 in “British Journal of Dermatology”

This study found that dermal papilla cells from human hair follicles form multi-layered aggregates when cultured in vitro, contrasting with the monolayer growth of dermal fibroblasts.

research Different Keratin Polypeptides in Epidermis and Other Epithelia of Human Skin: A Specific Cytokeratin of Molecular Weight 46,000 in Epithelia of the Pilosebaceous Tract and Basal Cell Epitheliomas

277 citations , October 1982 in “The Journal of Cell Biology”

This study found that the cytokeratin patterns in skin epithelia can distinguish between different types, with basal-cell epitheliomas showing a striking similarity to the pilosebaceous tract.