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    Case Report: Multimodal Contact Immunotherapy In Alopecia Areata: Long-Term Clinical Experience In The JAK Inhibitor Era

    February 2026 in “ Frontiers in Medicine ”
    Maira E. Herz-Ruelas, Miranda M. Contreras-Hernández, Ilse M. Salazar-Herz
    Studysummary This case series described five patients with chronic alopecia areata who successfully maintained long-term disease control using a combination of topical immunotherapy and other treatments over 9–15 years, highlighting the approach's continued value alongside novel therapies.
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    Research cited in this study 13

    1. Vitamin D and Alopecia Areata: From Mechanism to Therapeutic Implications Skin Appendage Disorders · 2025
    2. The Role of Minoxidil in the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis Journal of Clinical Medicine · 2024
    3. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023
    4. Efficacy of Different Concentrations of Intralesional Triamcinolone Acetonide for Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2019
    5. Immunotherapy for Resistant and Severe Alopecia Areata in a University Hospital Setting in Northern Mexico Australasian journal of dermatology · 2019
    6. The Role of Micronutrients in Alopecia Areata: A Review American Journal of Clinical Dermatology · 2017
    7. Pulse Corticosteroid Therapy With Oral Dexamethasone for the Treatment of Adult Alopecia Totalis and Universalis Journal of the American Academy of Dermatology · 2016
    8. Early Intervention with High-Dose Steroid Pulse Therapy Prolongs Disease-Free Interval of Severe Alopecia Areata: A Retrospective Study Annals of Dermatology · 2013
    9. Prevention and Treatment of Alopecia Areata with Quercetin in the C3H/HeJ Mouse Model Cell stress & chaperones · 2011
    10. Extensive Alopecia Areata: Not Necessarily Recalcitrant to Therapy International Journal of Trichology · 2011
    11. A Comparison of the Efficacy, Relapse Rate, and Side Effects Among Three Modalities of Systemic Corticosteroid Therapy for Alopecia Areata Dermatology · 2006
    12. Twice Weekly 5 mg Dexamethasone Oral Pulse in the Treatment of Extensive Alopecia Areata The Journal of Dermatology · 1999
    13. Efficacy of Topical Sensitizers in the Treatment of Alopecia Areata Journal of the American Academy of Dermatology · 1998