Vitamin D and Alopecia Areata: From Mechanism to Therapeutic Implications

April 2025 in “ Skin Appendage Disorders ”

Erick Alejandro Jiménez-Herrera, Bianca Eunice López-Zenteno, Eduardo Corona‐Rodarte, Ricardo Parra-Guerra, Rafael Zubirán, Luis Enrique Cano‐Aguilar, Carlos A. Barrera‐Ochoa, Daniel Asz‐Sigall

alopecia areata vitamin D vitamin D receptor VDR calcipotriol autoimmune disorder hair follicle homeostasis AA vitamin D deficiency

TLDR Vitamin D may help reduce severity and relapse of alopecia areata.

Alopecia areata (AA) is an autoimmune disorder affecting 1.7–2% of the global population, characterized by non-scarring hair loss. This review highlights the role of vitamin D in AA, focusing on its immunomodulatory effects and the importance of vitamin D receptor (VDR) in maintaining hair follicle homeostasis. Vitamin D deficiency and altered VDR expression are linked to increased disease severity. Emerging clinical data suggest that vitamin D supplementation and analogs like calcipotriol may help reduce disease severity and relapse rates, offering potential adjunctive therapeutic strategies for AA management.

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community Why are there no studies on Topical Vitamin D3 for AGA?

in Research/Science 11 upvotes 1 year ago

Topical Vitamin D3 may stimulate hair growth and has been used for Alopecia Areata. There is a question about the lack of research on its use for Androgenetic Alopecia (AGA).

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 6 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 2 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 674 upvotes 6 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community C’est terrible - at my wits end

in Female 450 upvotes 1 year ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 448 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.