Efficacy and Safety of Mesotherapy With 0.5% Minoxidil Versus Topical 2% Minoxidil for Female Androgenetic Alopecia: A Randomized Controlled Trial

    January 2026 in “ Dermatologic Therapy ”
    Xiaodan Wang, Wenjia Weng, Zhenzhen Yan, J Li, Bing Bing Song, Wei Zhu
    From the encyclopedia
    Mesotherapy →

    technique to inject very small amounts of beneficial chemicals into the scalp

    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Studysummary This study found that in patients with female androgenetic alopecia, mesodermal injection of 0.5% minoxidil was more effective in increasing hair density and improving hairline height than topical 2% minoxidil, with comparable safety over 16 weeks.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    This randomized controlled trial compared the efficacy and safety of mesotherapy with 0.5% minoxidil injections versus topical 2% minoxidil in treating female androgenetic alopecia (FAGA) over 16 weeks, involving 40 women. The mesotherapy group showed significantly greater improvements in hair density, diameter, and coverage, with hair density increasing from 33.10 to 41.80 hairs/cm² and hair diameter from 62.03 to 76.20 μm. Both treatments were well-tolerated, with no severe adverse effects reported. The study suggests that mesotherapy with 0.5% minoxidil is a safe and potentially more effective alternative to topical application, especially for patients who cannot tolerate or respond poorly to topical treatments. However, limitations include the small sample size and short duration, indicating a need for further research with larger samples and longer follow-up.
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