Long-Term Treatment with a 5-Alpha-Reductase Inhibitor Alleviates Depression-Like Behavior in Obese Male Rats

    July 2024 in “ Behavioural Brain Research ”
    Thiraphat Saengmearnuparp, Hiranya Pintana, Nattayaporn Apaijai … Siriporn C. Chattipakorn
    Studysummary In this study, male Wistar rats with obesity showed reduced depressive-like behaviors, brain inflammation, and oxidative stress after long-term finasteride treatment, suggesting potential benefits of finasteride in obese conditions, while lean rats experienced adverse effects including metabolic disturbances and depressive-like behaviors.
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    Research cited in this study 21

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