LncRNA H19 Inhibited Dermal Papilla Cell Senescence Process Through miR-29a by Targeting Wnt/β-Catenin Signaling Pathway

    Zhenyu Liu, Yushen Li, Qilin Yang … Ningxia Zhu
    Studysummary This research observed that overexpression of lncRNA H19 in human dermal papilla cells inhibited cell senescence and maintained hair follicle-inducing abilities by activating the Wnt signaling pathway, suggesting potential therapeutic strategies for androgenetic alopecia.
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    Research cited in this study 13

    1. Modeling Human Hair Follicles: Lessons from Animal Models and Beyond Biology · 2024
    2. Expression of Concern: Dermal Papilla Cell-Secreted Biglycan Regulates Hair Follicle Phase Transition and Regeneration by Activating Wnt/β-Catenin Experimental Dermatology · 2023
    3. Androgenetic Alopecia: Therapy Update Drugs · 2023
    4. Pharmacological Management of Pattern Hair Loss Indian Journal of Plastic Surgery · 2021
    5. Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration Journal of Advanced Research · 2020
    6. LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells Frontiers in Genetics · 2020
    7. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    8. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    9. Knockout of p16INK4a Promotes Aggregative Growth of Dermal Papilla Cells Revista Da Associacao Medica Brasileira · 2017
    10. Hair Growth Promoting and Anticancer Effects of p21-Activated Kinase 1 (PAK1) Inhibitors Isolated from Different Parts of Alpinia Zerumbet Molecules · 2017
    11. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    12. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    13. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007

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