Treatment of Alopecia Areata With JAK Inhibitors: A Review of the Literature

    January 2025 in “ Acta Dermatovenerologica Alpina Pannonica et Adriatica ”
    J Townsend, Aleksandar Godić
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    TLDR JAK inhibitors can help regrow hair in alopecia areata but have potential long-term risks and require careful monitoring.
    JAK inhibitors are a promising treatment for moderate-to-severe alopecia areata, with clinical trials showing that 33-40% of patients achieve near-complete scalp coverage within 6 months. Baricitinib and ritlecitinib have shown significant hair regrowth, with 38.8% and 31% of patients responding, respectively. While short-term safety is acceptable, long-term risks like serious infections and thrombosis need further study. Challenges include suboptimal response in up to half of patients, relapse after discontinuation, and limited long-term data. JAK inhibitors should be used for extensive or refractory cases, with careful monitoring. Future research should address long-term safety, treatment duration, and relapse prevention.
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      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 10 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 11 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community Should I get transplant #4 or just shave my head?

      in Transplants  171 upvotes 1 year ago
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      in Treatment  1 upvotes 2 years ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

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      in Research/Science  8 upvotes 2 years ago
      The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

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