Efficacy and Safety of Anti-Androgens in the Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

    August 2023 in “ EClinicalMedicine ”
    Simon Alesi, Maria Forslund, Johanna Melin … Aya Mousa
    Studysummary This study reported that anti-androgens combined with lifestyle modifications were more effective than metformin and lifestyle in reducing hirsutism and certain hormonal measures in women with PCOS, but they were not more effective than a placebo combined with lifestyle changes.
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    Research cited in this study 16

    1. Treatment Options for Hirsutism: A Systematic Review and Network Meta-Analysis The Journal of Clinical Endocrinology & Metabolism · 2018
    2. Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism: A Double-Blind Randomized Controlled Trial The Journal of Clinical Endocrinology & Metabolism · 2017
    3. Comparison of Finasteride, Metformin, and Finasteride Plus Metformin in PCOS Acta Endocrinologica · 2017
    4. The Prevalence and Phenotypic Features of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Human Reproduction · 2016
    5. Comprehensive Overview of Polycystic Ovary Syndrome Nature Reviews Disease Primers · 2016
    6. Androgen Excess: Investigations and Management Best Practice & Research in Clinical Obstetrics & Gynaecology · 2016
    7. Intermittent Low-Dose Finasteride Administration Is Effective for Treatment of Hirsutism in Adolescent Girls: A Pilot Study Journal of Pediatric and Adolescent Gynecology · 2014
    8. Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study The Journal of Clinical Endocrinology and Metabolism · 2013
    9. Treatment Options for Polycystic Ovary Syndrome International journal of women's health · 2011
    10. The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report Fertility and Sterility · 2008
    11. A Systematic Review of Commonly Used Medical Treatments for Hirsutism in Women Clinical endocrinology · 2007
    12. Intermittent Low-Dose Finasteride Is as Effective as Daily Administration for the Treatment of Hirsute Women Fertility and Sterility · 2004
    13. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003
    14. Australian Medicines Handbook 2003 Australian Prescriber · 2003
    15. Comparison of Diane 35 and Diane 35 Plus Finasteride in the Treatment of Hirsutism Fertility and Sterility · 2000
    16. Comparison of Finasteride Versus Flutamide in the Treatment of Hirsutism European journal of endocrinology · 1999