An Exploratory Analysis of 5-Alpha Reductase Inhibitors and Risk of Opioid Use Disorder Among Male Medicare Beneficiaries Receiving Prescription Opioid Medications

    July 2025 in “ American Journal on Addictions ”
    Abdelrahman Tawfik, T. Andrew Lister, Ainhoa Gómez-Lumbreras … Daniel C. Malone
    Studysummary This study suggests that using opioids along with 5αRI may reduce opioid use disorder risk in humans, supporting similar findings from animal studies.
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    Research cited in this study 16

    1. The Steroidogenic Inhibitor Finasteride Reverses Pramipexole-Induced Alterations in Probability Discounting Brain Research Bulletin · 2022
    2. The 5α-Reductase Inhibitor Finasteride Reduces Opioid Self-Administration in Animal Models of Opioid Use Disorder Journal of Clinical Investigation · 2021
    3. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    4. The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli Biomolecules · 2019
    5. The Risk of Dementia with the Use of 5 Alpha Reductase Inhibitors Journal of the neurological sciences · 2017
    6. The Cardiovascular Safety of Dutasteride ˜The œJournal of urology/˜The œjournal of urology · 2016
    7. An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia International Journal of Andrology · 2016
    8. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    9. Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis PubMed · 2015
    10. Decreased Alcohol Consumption Among Former Male Users of Finasteride with Persistent Sexual Side Effects: A Preliminary Report Alcoholism: Clinical and Experimental Research · 2013
    11. Finasteride Attenuates Pathological Gambling in Patients With Parkinson's Disease Journal of Clinical Psychopharmacology · 2012
    12. Inhibition of 5α-Reductase in the Nucleus Accumbens Counters Sensorimotor Gating Deficits Induced by Dopaminergic Activation Psychoneuroendocrinology · 2011
    13. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011
    14. Finasteride Treatment of Hair Loss in Women Annals of Pharmacotherapy · 2010
    15. Finasteride, a 5α-Reductase Inhibitor, Potentiates Antinociceptive Effects of Morphine, Prevents the Development of Morphine Tolerance and Attenuates Abstinence Behavior in the Rat Hormones and Behavior · 2007
    16. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006