In Silico Analysis of Imprinted Gene Expression in the Mouse Skin

June 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Alexandra K. Marr, Sabri Boughorbel, Mohammed Toufiq, Mohammed El Anbari, Aouatef Ismail Chouchane, Tomoshige Kino

imprinted gene network IGN genes hair cycle telogen phase anagen phase hair cycle regulation hair-loss disorders

TLDR IGN genes may regulate hair growth and could be targeted for hair-loss treatments.

The study conducted an in silico analysis of 16 imprinted gene network (IGN) genes in mouse skin, revealing their elevated expression during the telogen and early anagen phases of the hair cycle. These genes were identified as part of a larger network, acting as upstream regulators of hair cycle-regulated genes. The findings suggested a novel role for IGN genes in hair cycle regulation and proposed that their dysregulation could contribute to hair cycle-related syndromes. This highlighted the potential of targeting IGN gene expression as a therapeutic intervention for hair-loss disorders.

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