100 citations
,
July 2018 in “Journal of The American Academy of Dermatology” This study found that alopecia areata is linked with a higher prevalence of systemic and psychiatric diseases, suggesting that physicians should monitor for these potential comorbidities.
58 citations
,
July 2018 in “Journal of Allergy and Clinical Immunology” Alopecia areata severity is linked to increased TH1 and TH2 activity.
27 citations
,
March 2018 in “Allergy and asthma proceedings” This study found that Israeli patients with alopecia areata had a higher prevalence of comorbid conditions, including food allergies and chronic spontaneous urticaria, compared to matched controls.
77 citations
,
June 2017 in “Advances in Therapy” This review discusses recent advances and ongoing clinical trials in novel therapeutics for alopecia areata, despite the lack of current FDA-approved treatments for severe cases, and reports no new results.
12 citations
,
April 2017 in “Experimental and Therapeutic Medicine” This study found that patients with active severe alopecia areata exhibited decreased CD200 expression on T and B lymphocytes, which may be linked to an imbalance in Th1/Th2 immune equilibrium.
7 citations
,
January 2017 in “Dermatology” In this study, late-onset alopecia areata in Israeli patients was predominantly observed in females with mild disease, showing a high rate of complete hair regrowth but frequent relapses.
30 citations
,
May 2016 in “Expert Opinion on Biological Therapy” This review discusses immune pathways involved in alopecia areata and explores emerging, more targeted therapeutic strategies, noting their potential for better safety and effectiveness compared to traditional immune suppressants.
15 citations
,
April 2016 in “Medicine” This study reports that systemic lupus erythematosus patients with Evans syndrome often exhibited photosensitivity, hypocomplementemia, and elevated serum IgG, while lupus nephritis was less common, suggesting distinct clinical features.
176 citations
,
August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.
26 citations
,
September 2012 in “Journal of The American Academy of Dermatology” This study observed that patients with rapidly progressive alopecia areata may have a favorable prognosis regardless of treatment, and regenerated vellus hairs were linked to higher improvement or cure rates.
21 citations
,
February 2012 in “Journal of the European Academy of Dermatology and Venereology” This study found that late-onset alopecia areata is more common in women and tends to present with milder symptoms, with some patients achieving complete hair regrowth in mild cases.
38 citations
,
January 2012 in “Journal of Korean Medical Science” This study found that early-onset patients with alopecia universalis or a family history of alopecia areata showed worse prognosis compared to those with late-onset.
227 citations
,
November 2004 in “Medicine” This study found that late-onset systemic lupus erythematosus in a French cohort was characterized by a lower disease severity but reduced survival mainly attributed to aging-related factors.
275 citations
,
November 2002 in “International Journal of Dermatology” This study found that among an Asian population with alopecia areata, commonly first episodes occurred before age 40, with severe cases linked to psychological effects and treatments showing significant regrowth.
69 citations
,
July 2002 in “Clinical and Experimental Dermatology” This review discusses rodent models of alopecia areata and highlights genetic and epigenetic factors influencing its development, but reports no new experimental results.
64 citations
,
July 1997 in “Journal of The American Academy of Dermatology” This study found that eosinophils are a useful diagnostic feature for alopecia areata, especially when the typical "swarm of bees" lymphoid infiltrate is absent, helping differentiate it from trichotillomania.
46 citations
,
November 1995 in “The Journal of Dermatology” This study found that immunotherapy with DNCB or DPCP showed better therapeutic effects than intralesional triamcinolone acetonide for patients with bald areas greater than 50 cm², including alopecia totalis and universalis.
161 citations
,
March 1992 in “International Journal of Dermatology” This study analyzed survey responses from 800 alopecia areata patients and found a possible genetic association with increased insulin-dependent diabetes mellitus in relatives but not in the patients themselves.
164 citations
,
November 1989 in “Clinical and Experimental Dermatology” This retrospective study found that juvenile alopecia areata is more severe and has a worse prognosis than maturity-onset alopecia areata.
