Clinical Features of Systemic Lupus Erythematosus Patients Complicated with Evans Syndrome

    April 2016 in “ Medicine ”
    Lili Zhang, Xiuhua Wu, Laifang Wang, Jing Li, Hua Chen, Yan Zhao, Wenjie Zheng
    TLDR SLE patients with Evans syndrome often show blood issues and need careful monitoring and treatment.
    The study investigated the clinical features of systemic lupus erythematosus (SLE) complicated with Evans syndrome (ES) in 27 out of 5724 hospitalized SLE patients, finding ES to be rare (0.47%) and more common in women (81.5%). Hematologic abnormalities were often the initial presentation, with a median interval of 36 months to SLE diagnosis. Patients with ES had higher incidences of photosensitivity, hypocomplementemia, and elevated serum IgG, but lower incidence of lupus nephritis compared to those without ES. Treatment with glucocorticoids and immunosuppressants led to improvement in 92.6% of patients, though relapses were common. The study highlighted the need for close monitoring and tailored therapeutic strategies for managing SLE patients with ES.
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