Clinical Features of Systemic Lupus Erythematosus Patients Complicated with Evans Syndrome

The study investigated the clinical features of systemic lupus erythematosus (SLE) complicated with Evans syndrome (ES) in 27 out of 5724 hospitalized SLE patients, finding ES to be rare (0.47%) and more common in women (81.5%). Hematologic abnormalities were often the initial presentation, with a median interval of 36 months to SLE diagnosis. Patients with ES had higher incidences of photosensitivity, hypocomplementemia, and elevated serum IgG, but lower incidence of lupus nephritis compared to those without ES. Treatment with glucocorticoids and immunosuppressants led to improvement in 92.6% of patients, though relapses were common. The study highlighted the need for close monitoring and tailored therapeutic strategies for managing SLE patients with ES.