Immunogenetic and Metabolic Risk Factors in Male Androgenetic Alopecia: The Role of HLA-DRB1 Alleles and Vitamin D3 Deficiency

    Tuğba Tehçi, Ümit Türsen
    TLDR Certain genetic markers and low vitamin D3 levels are linked to male pattern baldness.
    This study investigates the role of immunogenetic factors and vitamin D3 deficiency in male androgenetic alopecia (AGA) by analyzing the HLA-DRB1 allele positivity in 85 male patients. The results indicate that certain HLA-DRB1 alleles, specifically HLA-DRB101, HLA-DRB104, and HLA-DRB111, are more frequently observed in patients with AGA. Additionally, 82% of the patients exhibited low vitamin D3 levels. The findings suggest that these factors are associated with AGA, and screening for them may aid in early diagnosis and treatment.
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