Malva verticillataseed extracts upregulate the Wnt pathway in human dermal papilla cells
August 2015
in “International Journal of Cosmetic Science”
TLDR Malva verticillata seed extract might help treat hair loss by activating hair growth signals in skin cells.
The study from 8 years ago demonstrated that Malva verticillata seed extracts, particularly myristoleic acid, could potentially treat hair loss by activating the Wnt/β-catenin signaling pathway in human dermal papilla cells (DPCs). The extract increased Wnt reporter activity and β-catenin levels in a concentration-dependent manner. Myristoleic acid was found to stimulate DPC proliferation and upregulate hair growth-related cytokines such as IGF-1, KGF, VEGF, and HGF. It also promoted the phosphorylation of MAPKs, including Akt and p38. These findings suggest that myristoleic acid from M. verticillata seeds may be a promising candidate for developing hair loss treatments.
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