Analysis of Histology and Long Noncoding RNAs Involved in the Rabbit Hair Follicle Density Using RNA Sequencing

January 2021 in “ Research Square (Research Square) ”

Haisheng Ding, Huiling Zhao, Xiaowei Zhao, Yunxia Qi, Xiaofei Wang, Dongwei Huang

hair follicle density long noncoding RNAs RNA sequencing lipid metabolism apoptosis JAK-STAT signaling pathway hedgehog signaling pathway

TLDR Long noncoding RNAs may help understand rabbit hair follicle density.

This study investigated the molecular mechanisms regulating hair follicle density in Wan strain Angora rabbits, focusing on differences between high and low wool production groups. Histological analysis showed higher hair follicle density in high wool production rabbits. RNA sequencing identified 50 differentially expressed long noncoding RNAs (lncRNAs) and 38 genes between the groups. Gene ontology analysis highlighted significant enrichment in processes related to lipid metabolism and transport, apoptosis, and signaling pathways such as JAK-STAT and hedgehog. Five lncRNAs were identified as potential regulators of hair follicle density. The study concluded that lncRNA profiles could enhance the understanding of molecular mechanisms governing hair follicle density.

View this study on researchsquare.com →

Discuss this study in the Community →

Research cited in this study

16 / 16 results

research The Functions of Ocu-miR-205 in Regulating Hair Follicle Development in Rex Rabbits

3 citations , April 2020

Ocu-miR-205 affects hair density in Rex rabbits by promoting cell changes and influencing hair follicle phases.

research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

35 citations , May 2019 in “Frontiers in genetics”

Non-coding RNAs play key roles in the hair growth cycle of Angora rabbits.

research Analyses of Histological and Transcriptome Differences in the Skin of Short-Hair and Long-Hair Rabbits

59 citations , February 2019 in “BMC Genomics”

Hair length in rabbits is linked to differences in lipid metabolism and cell death.

research Heat Stress Decreased Hair Follicle Population in Rex Rabbits

10 citations , December 2018 in “Journal of animal physiology and animal nutrition”

Heat stress reduced hair growth and affected related genes in rex rabbits.

research Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms

52 citations , September 2018 in “International Journal of Molecular Sciences”

Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.

research In Vivo Monitoring of Hair Cycle Stages via Bioluminescence Imaging of Hair Follicle NG2 Cells

14 citations , January 2018 in “Scientific reports”

Bioluminescence imaging can track hair follicle cells and help study hair regrowth.

research Integrated Analysis of Coding Genes and Non-Coding RNAs During Hair Follicle Cycle of Cashmere Goat (Capra Hircus)

129 citations , October 2017 in “BMC Genomics”

The study improved understanding of gene roles in cashmere goat hair growth, aiding future cashmere production.

research Highly Conserved Keratin-Associated Protein 7-1 Gene in Yak, Taurine, and Zebu Cattle

2 citations , January 2017 in “Folia biologica”

The KRTAP7-1 gene is very similar across different cattle and yak breeds and likely plays a role in hair strength and shape.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations , October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

research FGF5 Is a Crucial Regulator of Hair Length in Humans

136 citations , July 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

FGF5 gene mutations cause unusually long eyelashes by affecting hair growth regulation.

research Mutations In AEC Syndrome Skin Reveal A Role For p63 In Basement Membrane Adhesion, Skin Barrier Integrity And Hair Follicle Biology

33 citations , February 2012 in “British Journal of Dermatology”

Mutations in the p63 gene affect skin adhesion, barrier integrity, and hair growth.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research The Effects of Melatonin Treatment on Wool Production and Hair Follicle Cycle in Angora Rabbits

7 citations , January 2001 in “Annales de zootechnie”

Melatonin treatment increases wool production and improves fiber quality in angora rabbits.

research Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle

305 citations , December 2000 in “The EMBO Journal”

Inhibiting Bmp signaling disrupts hair growth and differentiation.

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

Hair follicle size is mainly influenced by the number of cells and extracellular matrix volume, with cell number having a larger impact.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.