The Hair Follicle as a Neuro-Immuno-Endocrine Organ: Implications in Hair Disorders and Regenerative Therapies

    January 2026
    Shaimaa Farouk
    Studysummary This review reports that hair follicles are dynamic neuro-immuno-endocrine organs with intrinsic signaling pathways, which play a crucial role in hair disorders like alopecia. It highlights emerging regenerative approaches targeting these pathways for hair restoration.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 27

    1. Telogen Effluvium: A Sequela of COVID-19 International Journal of Dermatology · 2020
    2. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
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    5. Association of Metabolic Syndrome With Female Pattern Hair Loss in Women: A Case-Control Study International Journal of Dermatology · 2016
    6. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial Stem Cells Translational Medicine · 2015
    7. Frontal Fibrosing Alopecia and Increased Scalp Sweating: Is Neurogenic Inflammation the Common Link Skin Appendage Disorders · 2015
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    9. Clinical, Histological, and Trichoscopic Correlations in Scalp Disorders Dermatology · 2015
    10. Efficacy and Safety of a Low-Level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-Controlled, Double-Blind Study American Journal of Clinical Dermatology · 2014
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    15. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study International Journal of Trichology · 2013
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    18. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
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