Alterations in the Hair Follicle Bacteriome and Mycobiome in Androgenetic Alopecia: A Cross-Sectional Study of 72 Patients and 24 Healthy Controls

    April 2026 in “ Clinical Cosmetic and Investigational Dermatology ”
    Beibei Miao, Xueke Zou, S M Yang … Menglong Ran
    Studysummary This study found that androgenetic alopecia involves fungal dysbiosis, with significant depletion of the commensal yeast Malassezia and enrichment of opportunistic microbes, affected by host factors and geography.
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    Research cited in this study 14

    1. Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment Drug Design Development and Therapy · 2025
    2. Skin Microbiome and Dermatitis: Focusing on Two Distinct Skin Diseases, Atopic Dermatitis and Androgenetic Alopecia YAKUGAKU ZASSHI · 2025
    3. Microbial Dysbiosis and Its Diagnostic Potential in Androgenetic Alopecia: Insights from Multi-Kingdom Sequencing and Machine Learning mSystems · 2025
    4. Research Progress on the Pathogenesis of Androgenetic Alopecia European Journal of Dermatology · 2025
    5. Micronutrients And Androgenetic Alopecia: A Systematic Review Molecular Nutrition & Food Research · 2024
    6. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    7. Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia Microorganisms · 2021
    8. Topical Ketoconazole for the Treatment of Androgenetic Alopecia: A Systematic Review Dermatologic Therapy · 2019
    9. Microbiome in the Hair Follicle of Androgenetic Alopecia Patients PLOS ONE · 2019
    10. The Role of the Microbiome in Scalp Hair Follicle Biology and Disease Experimental Dermatology · 2019
    11. Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss F1000Research · 2015
    12. Onion Juice (Allium Cepa L.), A New Topical Treatment For Alopecia Areata The Journal of Dermatology · 2002
    13. Androgenetic Alopecia and Microinflammation International Journal of Dermatology · 2000
    14. Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia Journal of The American Academy of Dermatology · 1993