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    JAK-Centric Explainable Few-Shot Gene-Expression Diagnosis Framework for Alopecia via MultiPLIER Priors and Relation-Style Set-to-Set Comparison

    January 2026 in “ Frontiers in Molecular Biosciences ”
    Nanlan Yu, Ling Ran, Xinrong Gong … Zhiqiang Song
    Studysummary This study identified a four-gene loop as a non-invasive biomarker that selectively activates in alopecia areata, providing a precise target for JAK inhibitor treatments.
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    Research cited in this study 10

    1. Predictive Factors for Treatment Responses to Baricitinib in Severe Alopecia Areata: A Retrospective, Multivariate Analysis of 70 Cases from a Single Center The Journal of Dermatology · 2025
    2. Janus Kinase Inhibitors for Alopecia Areata: A Narrative Review Indian journal of dermatology, venereology, and leprology · 2023
    3. Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A Case Control Study Skin Pharmacology and Physiology · 2022
    4. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    5. Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata JCI insight · 2021
    6. Pathomechanisms of Immune-Mediated Alopecia International Immunology · 2019
    7. New Drugs Under Investigation for the Treatment of Alopecias Expert Opinion on Investigational Drugs · 2019
    8. Recalcitrant Alopecia Areata Responsive to Leflunomide and Anthralin—Potentially Undiscovered JAK/STAT Inhibitors? Pediatric dermatology · 2018
    9. Comparison of Quality of Life in Patients with Androgenetic Alopecia and Alopecia Areata Anais Brasileiros De Dermatologia · 2018
    10. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017